Botryoid odontogenic cyst

Report of case found in routine imaginological examinations and an update of the literature

Authors

  • John Lennon Silva Cunha Tiradentes University https://orcid.org/0000-0002-0679-8485
  • Amanda Feitoza da Silva Tiradentes University
  • Joao Vitor Rocha Silva Tiradentes University
  • Juliana Batista Melo da Fonte Federal University of Sergipe
  • Bruno Torres Bezerra Tiradentes University
  • Sílvia Ferreira de Sousa Federal University of Minas Gerais
  • Ricardo Luiz Cavalcanti de Albuquerque-Júnior Tiradentes University

DOI:

https://doi.org/10.5935/2525-5711.20180027

Keywords:

Bone Diseases, Odontogenic Cysts, Mandible

Abstract

Botryoid odontogenic cyst (BOC) is a rare variant of the lateral periodontal cyst (LPC). As the biological behavior of BOC is variable and the literature is limited to that of individual case reports, there is no accepted consensus on the best management strategy. A 43-year-old Caucasian male was referred to a private dental clinic for routine radiographic examination. Extraoral and intraoral evaluations revealed no alterations. Panoramic radiography, periapical radiography, and cone beam computed tomography revealed a well-circumscribed osteolytic lesion of 2.0 cm in diameter, extending from the region of teeth 33 to 35. The provisional diagnostic was odontogenic keratocyst or lateral periodontal cyst. Histological analysis of the incisional biopsy revealed multiple cystic cavities lined by a thin nonkeratinized epithelium, exhibiting focal plaque-like thickenings, surrounded by a dense fibrous capsule. The diagnosis was BOC. The purpose of this study was to critically analyze the clinical and radiologic features of BOC based on case reports and case series published in the literature from 1973 to 2018 and to add a new one from our files.

Author Biographies

John Lennon Silva Cunha, Tiradentes University

Laboratory of Morphology and Experimental Pathology, Institute of Technology and Research

Amanda Feitoza da Silva, Tiradentes University

Department of Dentistry

Joao Vitor Rocha Silva, Tiradentes University

Laboratory of Morphology and Experimental Pathology, Institute of Technology and Research

Juliana Batista Melo da Fonte, Federal University of Sergipe

Department of Dentistry

Bruno Torres Bezerra, Tiradentes University

Department of Dentistry

Sílvia Ferreira de Sousa, Federal University of Minas Gerais

School of Dentistry, Oral Surgery and Pathology Department

Ricardo Luiz Cavalcanti de Albuquerque-Júnior, Tiradentes University

Laboratory of Morphology and Experimental Pathology, Institute of Technology and Research

References

Weathers DR, Waldron CA. Unusual multilocular cysts of the jaws (botryoid odontogenic cysts). Oral Surg Oral Med Oral Pathol. 1973;36:235-41.

Redman RS, Paal E, Chauhan S, Avers R, Bayley N. Botryoid odontogenic cyst. Exploration of proliferative activity, apoptosis and expression of TP53 and BCL2 compared to the histologically identical lateral periodontal and gingival cysts. Biotech Histochem. 2017;92:569-76. DOI: 10.1080/10520295.2017.1367231

Hethcox JM, Mackey SA, Fowler CB, Kirkpatrick TC, Deas DE. Case report: Diagnosis and treatment of a botryoid odontogenic cyst found in the maxillary anterior region. J Endod. 2010;36:751-4. DOI: 10.1016/j.joen.2010.01.013

Nam JH, Kim DY, Park YJ, Ahn JH, Gang TI, Park MH, et al. Botryoid Odontogenic Cyst on Mandibular Anterior and Both Body Area: a Case Report. J Korean Assoc Maxillofac Plast Reconstr Surg. 2010;32:368-72.

Johnston D, Parasha P, Closmann J. Botryoid Odontogenic Cyst: Case Report. Int J Med Pharm Case Rep. 2015;4:25-9. DOI: 10.9734/IJMPCR/2015/16925

El-Naggar AK, Chan JKC, Grandis JR, Takata T, Slootweg PJ, eds. World Health Organization Classification of Head and Neck Tumours. Lyon: IARC Press; 2017.

Farina VH, Brandao AA, Almeida JD, Cabral LA. Clinical and histologic features of botryoid odontogenic cyst: a case report. J Med Case Rep. 2010;4:260. DOI: 10.1186/1752-1947-4-260

Santos PP, Freitas VS, Freitas Rde A, Pinto LP, Souza LB. Botryoid odontogenic cyst: a clinicopathologic study of 10 cases. Ann Diagn Pathol. 2011;15:221-4. DOI: 10.1016/j.anndiagpath. 2010.03.008

Chrcanovic BR, Gomez RS. Gingival cyst of the adult, lateral periodontal cyst, and botryoid odontogenic cyst: An updated systematic review. Oral Dis. 2017 Nov 20. DOI: 10.1111/ odi.12808. [Epub ahead of print]

Gurol M, Burkes EJ Jr, Jacoway J. Botryoid odontogenic cyst: analysis of 33 cases. J Periodontol. 1995;66:1069-73. DOI: 10.1902/jop.1995.66.12.1069

Méndez P, Junquera L, Gallego L, Baladrón J. Botryoid odontogenic cyst: clinical and pathological analysis in relation to recurrence. Med Oral Patol Oral Cir Bucal. 2007;12:E594-8.

Vidaković B, Uljanić I, Grgurević J, Perić B, Manojlović S. Botryoid Cyst, a Rare Type of Odontogenic Cyst. Acta Clin Croat. 2016;55(3):510-4. DOI: 10.20471/acc.2016.55.03.24

Albuquerque Júnior RLC, Pereira JC, Fakouri R, Lessa Filho LS. Cisto odontogênico botrióide: relato de um caso. Rev Bras Patol Oral. 2005;4:12-6.

Goncalves R, Ribeiro Júnior O, Borba AM, Ribeiro ANC, Sugaya NN, Guimaraes Júnior J. Botryoid odontogenic cyst: case report with etiopathogenic, diagnostic and therapeutic considerations. RGO Rev Gaúch Odontol. 2015;63:343-6. DOI: 10.1590/1981-86372015000300015618

Lindh C, Larsson A. Unusual jaw-bone cysts. J Oral Maxillofac Surg. 1990;48:258-63.

Chrcanovic BR, Gomez RS. Glandular odontogenic cyst: An updated analysis of 169 cases reported in the literature. Oral Dis. 2018;24:717-24. DOI: 10.1111/odi.12719

Chrcanovic BR, Gomez RS. Recurrence probability for keratocystic odontogenic tumors: An analysis of 6427 cases. J Craniomaxillofac Surg. 2017;45:244-51. DOI: 10.1016/j.jcms.2016.11.010

Kichi E, Enokiya Y, Muramatsu T, Hashimoto S, Inoue T, Abiko Y, et al. Cell proliferation, apoptosis and apoptosisrelated factors in odontogenic keratocysts and in dentigerous cysts. J Oral Pathol Med. 2005;34:280-6. DOI: 10.1111/j.1600-0714.2005.00314.x

Tsuneki M, Yamazaki M, Cheng J, Maruyama S, Kobayashi T, Saku T. Combined immunohistochemistry for the differential diagnosis of cystic jaw lesions: its practical use in surgical pathology. Histopathology. 2010;57:806-13. DOI: 10.1111/j.1365-2559.2010.03712.x

Cox DP. p53 expression and mutation analysis of odontogenic cysts with and without dysplasia. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:90-8. DOI: 10.1016/j. tripleo.2011.07.027

Diniz MG, Gomes CC, de Castro WH, Guimaraes AL, De Paula AM, Amm H, et al. miR-15a/16-1 influences BCL2 expression in keratocystic odontogenic tumors. Cell Oncol (Dordr). 2012;35:285-91. DOI: 10.1007/s13402-012-0087-3

Byun JH, Kang YH, Choi MJ, Park BW. Expansile keratocystic odontogenic tumor in the maxilla: immunohistochemical studies and review of literature. J Korean Assoc Oral Maxillofac Surg. 2013;39:182-7. DOI: 10.5125/jkaoms.2013.39.4.182

Shimada Y, Katsube K, Kabasawa Y, Morita K, Omura K, Yamaguchi A, et al. Integrated genotypic analysis of hedgehog-related genes identifies subgroups of keratocystic odontogenic tumor with distinct clinicopathological features. PLoS One. 2013;8:e70995. DOI: 10.1371/journal.pone.0070995

Downloads

Published

2019-01-15

How to Cite

1.
Cunha JLS, Silva AF da, Silva JVR, Fonte JBM da, Bezerra BT, Sousa SF de, et al. Botryoid odontogenic cyst: Report of case found in routine imaginological examinations and an update of the literature. J Oral Diagn [Internet]. 2019 Jan. 15 [cited 2024 Sep. 19];4:1-8. Available from: https://jordi.com.br/revista/article/view/115

Issue

Section

Case Report