Mucosa-associated lymphoid tissue lymphoma in labial minor salivary glands - case report and literature review
DOI:
https://doi.org/10.5935/2525-5711.20190008Keywords:
Minor Salivary Glands, Marginal Lymphoma B-Cell, Treatment OutcomeAbstract
Mucosa-associated lymphatic tissue (MALT) lymphomas commonly occur in the stomach however, rare cases of MALT lymphomas involve the minor salivary gland. We did a literature review and described the fourth case in the English literature of adults affected by a MALT lymphoma in the lip. A 68-year-old woman with probable primary Sjögren’s syndrome (SS) was referred to our dentistry and stomatology service, complaining that her lower lip had progressively thickened during the past 4 years. An incisional biopsy was performed, and the microscopic examination showed a dense, diffuse lymphoplasmacytic infiltration of the salivary glands, with plasmacytic differentiation. The immunohisto- chemical analysis revealed diffuse positivity of the neoplastic cells for CD20 and BCL-2; the plasma cells were positive for CD138 and Lambda, which was consistent with MALT lymphoma. SS and Immunoglobulin G4-related disease were excluded. The total regression of the lesion was obtained after treatment with surgery, chemotherapy, and radiotherapy.
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Copyright (c) 1969 Marina Kimie Oba, Leandro Dorigan de-Macedo, Ana Carolina Fragoso Motta, Hilton Marcos Alves Ricz, Luiz Carlos Conti de-Freitas, Fabiano Pinto Saggioro, Lara Maria Alencar Ramos Innocentini
This work is licensed under a Creative Commons Attribution 4.0 International License.
