Adenomatoid odontogenic tumor: an unusual histological presentation with
DOI:
https://doi.org/10.5935/2525-5711.20180006Keywords:
Odontogenic Tumors, Maxilla, NeoplasmsAbstract
Adenomatoid odontogenic tumor (AOT) is a relatively rare odontogenic tumor derived from odontogenic epithelium. Although there have been many reports regarding the histo- logical spectrum of AOT, only a few have highlighted unusual histological presentations. A 28-year-old female presented with a painless swelling in the maxillary anterior region. Radiological examinations revealed a well-defined unilocular lesion, with sclerotic margins, containing foci of slightly radiopaque material and promoting root divergence between teeth 22 and 23. An incisional biopsy showed spindle-shaped cells forming sheets, strands, and whorled masses, together with ductlike structures, throughout a scanty fibrous stroma. In some areas, sheets of polyhedral epithelial cells with prominent intercellular bridges, mild pleomorphism, and droplets of amyloidlike material were observed. The diagnosis was AOT with “Pindborg-like” differentiation. The occurrence of such differentiation in AOT seems to represent the caricatures of the enamel organ itself and is believed to be an altered phenotype of the tumor.
References
Wright JM, Vered M. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors. Head Neck Pathol. 2017;11:68-77. DOI: 10.1007/s12105-017-0794-1
Chrcanovic BR, Gomez RS. Calcifying epithelial odontogenic tumor: An updated analysis of 339 cases reported in the literature. J Craniomaxillofac Surg. 2017;45:1117-23. DOI: 10.1016/j.jcms.2017.05.007
Kaushal S, Mathur SR, Vijay M, Rustagi A. Calcifying epithelial odontogenic tumor (Pindborg tumor) without calcification: A rare entity. J Oral Maxillofac Pathol. 2012;16:110-2. DOI: 10.4103/0973-029X.92985
Kalia V, Kalra G, Kaushal N, Sharma V, Vermani M. Maxillary adenomatoid odontogenic tumor associated with a premolar. Ann Maxillofac Surg. 2015;5:119-22. DOI: 10.4103/2231-0746.161118
Damm DD, White DK, Drummond JF, Poindexter JB, Henry BB. Combined epithelial odontogenic tumor: adenomatoid odontogenic tumor and calcifying epithelial odontogenic tumor. Oral Surg Oral Med Oral Pathol. 1983;55:487-96.
Bingham RA, Adrian JC. Combined epithelial odontogenic tumor-adenomatoid odontogenic tumor and calcifying epitelial odontogenic tumor: report of a case. J Oral Maxillofac Surg. 1986;44:574-7.
Miyake M, Nagahata S, Nishihara J, Ohbayashi Y. Combined adenomatoid odontogenic tumor and calcifying epitelial odontogenic tumor: report of case and ultrastructural study. J Oral Maxillofac Surg. 1996;54:788-93.
Montes Ledesma C, Mosqueda Taylor A, Romero de León E, de la Piedra Garza M, Goldberg Jaukin P, Portilla Robertson J. Adenomatoid odontogenic tumour with features of calcifying epithelial odontogenic tumour. (The so-called combined epithelial odontogenic tumour.) Clinico-pathological report of 12 cases. Eur J Cancer B Oral Oncol. 1993;29B:221-4.
Mosqueda-Taylor A, Carlos-Bregni R, Ledesma-Montes C, Fillipi RZ, de Almeida OP, Vargas PA. Calcifying epithelial odontogenic tumor-like areas are common findings in adenomatoid odontogenic tumors and not a specific entity. Oral Oncol. 2005;41:214-5.
Mutalik VS, Shreshtha A, Mutalik SS, Radhakrishnan R. Adenomatoid odontogenic tumor: A unique report with histological diversity. J Oral Maxillofac Pathol. 2012;16:118-21. DOI: 10.4103/0973-029X.92987
Takeda Y, Kudo K. Adenomatoid odontogenic tumor associated with calcifying epithelial odontogenic tumor. Int J Oral Maxillofac Surg. 1986;15:469-73.
Siar CH, Ng KH. Combined calcifying epithelial odontogenic tumor and adenomatoid odontogenic tumor. Int J Oral Maxillofac Surg. 1987;16:214-6.
Okada Y, Mochizuki K, Sigimura M, Noda Y, Mori M. Odontogenic tumor with combined characteristics of adenomatoid odontogenic and calcifying epithelial odontogenic tumors. Pathol Res Pract. 1987;182:647-57.
Siar CH, Ng KH. The combined epithelial odontogenic tumor in Malaysians. Br J Oral Maxillofac Surg. 1991;29:106-9.
More C, Das S, Gupta S, Bhavsar K. Mandibular adenomatoid odontogenic tumor: Radiographic and pathologic correlation. J Nat Sci Biol Med. 2013;4:457-62. DOI: 10.4103/0976-9668.116965
Philipsen HP, Reichart PA, Siar CH, Ng KH, Lau SH, Zhang X, et al. An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: a collaborative retrospective study. J Oral Pathol Med. 2007;36:383-93. DOI: 10.1111/j.1600-0714.2007.00536.x
Buchner A, David R, Carpenter W, Leider A. Pigmented lateral periodontal cyst and other pigmented odontogenic lesions. Oral Dis. 1996;2:299-302.
Santos JN, Lima FO, Romério P, Souza VF. Adenomatoid odontogenic tumor: an unusual case exhibiting cribriform aspect. Quintessence Int. 2008;39:777-81.
Mohanty N, Routray S, Swain N, Ingale Y. Adenomatoid odontogenic tumor with clear cell changes. Indian J Pathol Microbiol. 2014;57:290-3.
Agarwal A, Giri KY, Alam S. The interrelationship of adenomatoid odontogenic tumour and dentigerous cyst: a report of a rare case and review of the literature. Case Rep Pathol. 2012;2012:358609.
Gomez RS, Castro WH, Gomes CC, Loyola AM. Adenomatoid odontogenic tumor associated with odontoma: a case report and critical review of the literature. Head Face Med. 2013;9:20.
Yamazaki M, Maruyama S, Abé T, Babkair H, Fujita H, Takagi R, et al. Hybrid ameloblastoma and adenomatoid odontogenic tumor: report of a case and review of hybrid variations in the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:e12-8.
Shephard M, Coleman H. Simultaneous adenomatoid odontogenic and keratocystic odontogenic tumours in a patient with Gorlin-Goltz syndrome. Aust Dent J. 2014;59:121-4.
Nascimento GJ, Pereira KM, Nonaka CF, Medeiros AM, Galvao HC. Calcifying epithelial odontogenic tumor of the maxilla. Braz J Otorhinolaryngol. 2009;75:468. DOI: 10.1590/S1808-86942009000300026
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 1969 John Lennon Silva Cunha, Amanda Feitoza da Silva, Juliana Batista Melo da-Fonte, Raimundo Silva Rocha, Maria de Fátima Batista de-Melo, Ricardo Luiz Cavalcanti de Albuquerque-Júnior
This work is licensed under a Creative Commons Attribution 4.0 International License.
