Prevalence of desquamative gingivitis in patients with oral lichen planus

Authors

  • Thaís Cristina Esteves-Pereira Universidade Estadual de Campinas
  • Milena Moraes de-Carvalho Universidade do Estado de São Paulo
  • Isabella Rodrigues de-Almeida Universidade Federal de Alfenas
  • Carine Ervolino de-Oliveira Universidade Federal de Alfenas
  • João Adolfo Costa Hanemann Universidade Federal de Alfenas
  • Felipe Fornias Sperandio University of Saskatchewan
  • Marina Lara de-Carli Universidade Federal de Alfenas https://orcid.org/0000-0002-1133-6242

DOI:

https://doi.org/10.5935/2525-5711.20230223

Keywords:

Autoimmune Diseases, Gingivitis, Lichen Planus, Oral, Prevalence

Abstract

Introduction: Given the stress-related nature of desquamative gingivitis (DG), knowing its clinical and epidemiological aspects becomes essential during the COVID-19 pandemic. Therefore, the aim of the present study was to assess the prevalence of DG in patients with oral lichen planus (OLP). Material and methods: All cases displaying clinical and histopathological diagnoses of OLP, treated at our institution from 2000 to 2019 and presenting DG lesions at the time of initial examination were included in the study. Epidemiological, clinical and treatment data were analyzed, including OLP classification. Results: The results showed that 23.3% of the cases presented DG at the time of diagnosis, all were women, with a mean of 46 years old, and diagnosed with erosive OLP. Most were White; the most frequent occupations were homemaker and general services assistant. Half of the included patients presented lesions both in marginal and/or inserted gingiva in the anterior and posterior regions, and the majority (71.4%) related pain or discomfort or burning sensation. Topical triamcinolone acetonide aqueous solution ranging from 0.1%, 0.2% and 0.3% was prescribed for all patients, showing lesion recurrence in 21.4% of them. Conclusion: DG affected women with an average age of 46 years. Triamcinolone acetonide was the drug of choice for the treatment of DG; however, the recurrence rate was high. Therefore, the findings of this study highlight the need for further studies to elucidate the DG behavior and the lesion response to different therapies.

Author Biographies

Thaís Cristina Esteves-Pereira, Universidade Estadual de Campinas

Oral Diagnosis Department

Milena Moraes de-Carvalho, Universidade do Estado de São Paulo

Department of Diagnosis and Surgery

Isabella Rodrigues de-Almeida, Universidade Federal de Alfenas

School of Dentistry

Carine Ervolino de-Oliveira, Universidade Federal de Alfenas

Department of Pathology and Parasitology

João Adolfo Costa Hanemann, Universidade Federal de Alfenas

School of Dentistry

Felipe Fornias Sperandio, University of Saskatchewan

College of Dentistry

Marina Lara de-Carli, Universidade Federal de Alfenas

School of Dentistry

References

Sciuca AM, Toader MP, Stelea CG, Maftei GA, Ciurcanu OE, Stefanescu OM, et al. Desquamative gingivitis in the context of autoimmune bullous dermatoses and lichen planus-challenges in the diagnosis and treatment. Diagnostics. 2022;12(7):1754. DOI: https://doi.org/10.3390/DIAGNOSTICS12071754

Shaqman M, Hamdan A, Karadsheh O, Sawair F, Hassona Y. Desquamative gingivitis: a challenging diagnosis for clinicians. Br Dental J. 2020;229:26-30. DOI: https://doi.org/10.1038/s41415-020-1848-4

Magliocca KR, Fitzpatrick SG. Autoimmune disease manifestations in the oral cavity. Surg Pathol Clin. 2017;10(1):57-88. DOI: https://doi.org/10.1016/J.PATH.2016.11.001

Ramesh A, Bhat RM, Madhumita M, Jaganathan P, Ramesh A, Bhat RM, et al. Desquamative gingivitis in dermatological disorders. Indian J Dermatol Venereol Leprol 2021;87(3):446-51. DOI: https://doi.org/10.25259/IJDVL_130_20

Carrozzo M, Porter S, Mercadante V, Fedele S. Oral lichen planus: a disease or a spectrum of tissue reactions? Types, causes, diagnostic algorhythms, prognosis, management strategies. Periodontol. 2019 May;80(1):105-25. DOI: https://doi.org/10.1111/PRD.12260

Maderal AD, Lee Salisbury P, Jorizzo JL. Desquamative gingivitis: clinical findings and diseases. J Am Acad Dermatol. 2018 May;78(5):839-48. DOI: https://doi.org/10.1016/J.JAAD.2017.05.056

Giuliani M, Troiano G, Cordaro M, Corsalini M, Gioco G, lo Muzio L, et al. Rate of malignant transformation of oral lichen planus: a systematic review. Oral Dis. 2019;25(3):693-709. DOI: https://doi.org/10.1111/ODI.12885

Elenbaas A, Enciso R, Al-Eryani K. Oral lichen planus: a review of clinical features, etiologies, and treatments. Dentistry Rev. 2022;2(1):100007. DOI: https://doi.org/10.1016/J.DENTRE.2021.100007

Porras-Carrique T, González-Moles MÁ, Warnakulasuriya S, Ramos-García P. Depression, anxiety, and stress in oral lichen planus: a systematic review and meta-analysis. Clin Oral Investig. 2022;26:1391-408. DOI: https://doi.org/10.1007/S00784-021-04114-0

Li K, He W, Hua H. Characteristics of the psychopathological status of oral lichen planus: a systematic review and meta-analysis. Aust Dent J. 2022;67(2):113-24. DOI: https://doi.org/10.1111/adj.12896

Alaizari NA, Al-Maweri SA, Al-Shamiri HM, Tarakji B, Shugaa-Addin B. Hepatitis C virus infections in oral lichen planus: a systematic review and meta-analysis. Aust Dent J. 2016;61(3):282-7. DOI: https://doi.org/10.1111/ADJ.12382

Porras-Carrique T, Ramos-García P, Aguilar-Diosdado M, Warnakulasuriya S, González-Moles MÁ. Autoimmune disorders in oral lichen planus: a systematic review and meta-analysis. Oral Dis. 2022 Jan 09; [Epub ahead of print]. DOI: https://doi.org/10.1111/ODI.14127

Burgos-Blasco P, Fernandez-Nieto D, Selda-Enriquez G, Melian-Olivera A, Perosanz-Lobo D, Dominguez-Santas M, et al. COVID‐19: a possible trigger for oral lichen planus? Int J Dermatol. 2021;60(7):882. DOI: https://doi.org/10.1111/IJD.15529

Saleh W, SHawky E, Halim GA, Ata F. Oral lichen planus after COVID-19, a case report. Ann Med Surg. 2021;72:103051. DOI: https://doi.org/10.1016/J.AMSU.2021.103051

Sood A, Raghavan S, Batra P, Sharma K, Talwar A. Rise and exacerbation of oral lichen planus in the background of SARS-CoV-2 infection. Med Hypotheses. 2021 Nov;156:110681. DOI: https://doi.org/10.1016/J.MEHY.2021.110681

Cheng YSL, Gould A, Kurago Z, Fantasia J, Muller S. Diagnosis of oral lichen planus: a position paper of the American Academy of Oral and Maxillofacial Pathology. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016 Sep;122(3):332-54. DOI: https://doi.org/10.1016/J.OOOO.2016.05.004

Zakrzewska JM, Chan ESY, Thornhill MH. A systematic review of placebo‐controlled randomized clinical trials of treatments used in oral lichen planus. Br J Dermatol. 2005 Aug;153(2):336-41. DOI: https://doi.org/10.1111/J.1365-2133.2005.06493.X

Abdalla SM, Ettman CK, Cohen GH, Galea S. Mental health consequences of COVID-19: a nationally representative cross-sectional study of pandemic-related stressors and anxiety disorders in the USA. BMJ Open. 2021;11(8):e044125. DOI: https://doi.org/10.1136/BMJOPEN-2020-044125

Wu J, Wu Y, Tian Y. Temporal associations among loneliness, anxiety, and depression during the COVID-19 pandemic period. Stress Health. 2022;38:90-101. DOI: https://doi.org/10.1002/SMI.3076

Kujawa A, Green H, Compas BE, Dickey L, Pegg S. Exposure to COVID-19 pandemic stress: associations with depression and anxiety in emerging adults in the United States. Depress Anxiety. 2020 Nov;37(12):1280-8. DOI: https://doi.org/10.1002/DA.23109

Ministério da Saúde (BR). Coronavírus Brasil [Internet]. Brasília (DF): Ministério da Saúde; [access in 2022 Sep 18]. Available from: https://covid.saude.gov.br/

Russo G, Levi ML, Alves MTSS, Oliveira BLCA, Carvalho RHDSBF, Andrietta LS, et al. How the 'plates' of a health system can shift, change and adjust during economic recessions: a qualitative interview study of public and private health providers in Brazil's São Paulo and Maranhão states. PLoS One 2020;15(10):e0241017. DOI: https://doi.org/10.1371/JOURNAL.PONE.0241017

Alpino TMA, Santos CRB, Barros DC, Freitas CM. COVID-19 and food and nutritional (in)security: action by the Brazilian Federal Government during the pandemic, with budget cuts and institutional dismantlement. Cad Saúde Pública. 2020;36(8):e00161320. DOI: https://doi.org/10.1590/0102-311X00161320

González-Moles MÁ, Warnakulasuriya S, González-Ruiz I, González-Ruiz L, Ayén Á, Lenouvel D, et al. Worldwide prevalence of oral lichen planus: a systematic review and meta-analysis. Oral Dis. 2021;27(4):813-28. DOI: https://doi.org/10.1111/ODI.13323

Li C, Tang X, Zheng X, Ge S, Wen H, Lin X, et al. Global prevalence and incidence estimates of oral lichen planus: a systematic review and meta-analysis. JAMA Dermatol. 2020 Jan;156(2):172-81. DOI: https://doi.org/10.1001/jamadermatol.2019.3797

Sridharan K, Sivaramakrishnan G. Interventions for oral lichen planus: a systematic review and network meta-analysis of randomized clinical trials. Aust Dent J. 2021 Mar;66(3):295-303. DOI: https://doi.org/10.1111/adj.12835

Vadivel JK, Ezhilarasan D, Govindarajan M, Somasundaram E. Therapeutic effectiveness of alternative medications in oral lichen planus: a systematic review. J Oral Maxillofac Pathol. 2020;24(2):344-351. DOI: https://doi.org/10.4103/JOMFP.JOMFP_68_20

Sandhu S, Klein BA, Al-Hadlaq M, Chirravur P, Bajonaid A, Xu Y, et al. Oral lichen planus: comparative efficacy and treatment costs-a systematic review. BMC Oral Health. 2022;22(1):161. DOI: https://doi.org/10.1186/S12903-022-02168-4/FIGURES/2

García-Pola MJ, González-Álvarez L, Garcia-Martin JM. Treatment of oral lichen planus. Systematic review and therapeutic guide. Medicina Clínica. 2017 Oct;149(8):351-62. DOI: https://doi.org/10.1016/J.MEDCLE.2017.09.013

Lodi G, Manfredi M, Mercadante V, Murphy R, Carrozzo M. Interventions for treating oral lichen planus: corticosteroid therapies. Cochrane Database Syst Rev. 2020;(2):CD001168. DOI: https://doi.org/10.1002/14651858.CD001168.PUB3

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Published

2023-01-10

How to Cite

1.
Esteves-Pereira TC, de-Carvalho MM, de-Almeida IR, de-Oliveira CE, Hanemann JAC, Sperandio FF, et al. Prevalence of desquamative gingivitis in patients with oral lichen planus. J Oral Diagn [Internet]. 2023 Jan. 10 [cited 2024 Sep. 19];8:1-6. Available from: https://jordi.com.br/revista/article/view/15

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