Aggressive adenomatoid odontogenic tumor
an uncommon case report and discussion on the differential diagnosis
DOI:
https://doi.org/10.5935/2525-5711.20180002Keywords:
Ameloblastoma, Diagnosis, Differential, MandibleAbstract
Differential diagnosis between ameloblastomas (AMB) and adenomatoid odontogenic tumor (AOT) seldom cause difficulties due to classic histopathological presentations. Adenoid ameloblastoma with dentinoid (AAD) is a rare variant of AMB which can be misdiagnosed as AOT. We report a case of a 12-year-old female presenting a painless swelling in the anterior region of the mandible. Panoramic radiograph and cone beam CT scans demonstrated large unilocular osteolytic lesion extending from 44 to 32 and involving the impacted 43. Tumor caused teeth displacement and both vestibular and lingual cortical perforation. Histopathology revealed cuboidal and spindle-shaped cells arranged in nests and rosettes, solid, duct-like and whorled areas, and foci of calcification and dentin-like material were evident. The diagnosis was aggressive AOT. Because of the similarities of the histologic features of AOT and AAD, we intend to provide a discussion on the clinicopathologic criteria for establishing the differential diagnosis of these entities
References
Oliveira MR, Gabrielli MA, Gabrielli MF, De Andrade CR, Silva BN, Pereira-Filho VA. Unusual Adenomatoid Odontogenic Tumor. J Craniofac Surg. 2016;27:e139-41. DOI: 10.1097/SCS.0000000000002391
Narayanan VS, Naidu G, Ragavendra R, Mhaske-Jedhe S, Haldar M. Adenomatoid odontogenic tumor of the mandible with unusual radiographic features: A case report. Imaging Sci Dent. 2013;43:111-5. DOI: 10.5624/isd.2013.43.2.111
Dhupar V, Akkara F, Khandelwal P. An unusually large aggressive adenomatoid odontogenic tumor of maxilla involving the third molar: A clinical case report. Eur J Dent. 2016;10:277-80. DOI: 10.4103/1305-7456.178308
Loyola AM, Cardoso SV, de Faria PR, Servato JP, Eisenberg AL, Dias FL, et al. Adenoid ameloblastoma: clinicopathologic description of five cases and systematic review of the current knowledge. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015;120:368-77. DOI: 10.1016/j.oooo.2015.05.011
Wright JM, Vered M. Update from the 4th Edition of the World Health Organization Classification of Head and Neck Tumours: Odontogenic and Maxillofacial Bone Tumors. Head Neck Pathol. 2017;11:68-77. DOI: 10.1007/s12105-017-0794-1
Philipsen HP, Reichart PA, Siar CH, Ng KH, Lau SH, Zhang X, et al. An updated clinical and epidemiological profile of the adenomatoid odontogenic tumour: a collaborative retrospective study. J Oral Pathol Med. 2007;36:383-93. DOI: 10.1111/j.1600-0714.2007.00536.x
Mohamed A, Singh AS, Raubenheimer EJ, Bouckaert MM. Adenomatoid odontogenic tumour: review of the literature and an analysis of 33 cases from South Africa. Int J Oral Maxillofac Surg. 2010;39:843-6. DOI: 10.1016/j.ijom.2010.06.014
More C, Das S, Gupta S, Bhavsar K. Mandibular adenomatoid odontogenic tumor: Radiographic and pathologic correlation. J Nat Sci Biol Med. 2013;4:457-62. DOI: 10.4103/0976-9668.116965
Garg D, Palaskar S, Shetty VP, Bhushan A. Adenomatoid odontogenic tumor - hamartoma or true neoplasm: a case report. J Oral Sci. 2009;51:155-9. DOI: 10.2334/josnusd.51.155
Manjunatha BS, Harsh A, Purohit S, Naga MV. Adenomatoid odontogenic tumor associated with a dentigerous cyst. J Cancer Res Ther. 2015;11:649. DOI: 10.4103/0973-1482.138120
Brannon RB. Adenoid Ameloblastoma with Dentinoid. Washington: Armed Forces Institute of Pathology. ROPCOM; 1994. p. 1-94.
Kumar K, Shetty DC, Wadhwan V, Dhanapal R, Singh HP. Dentinoameloblastoma with ghost cells: A rare case report with emphasis on its biological behavior. Dent Res J (Isfahan). 2013;10:103-7. DOI: 10.4103/1735-3327.111809
Saxena K, Jose M, Chatra L, Sequiera J. Adenoid ameloblastoma with dentinoid. J Oral Maxillofac Pathol. 2012;16:272-6. DOI: 10.4103/0973-029X.99088
Sonone A, Hande A, Chaudhary M, Bonde R, Sheorain A, Agni N. Adenoid ameloblastoma with dentinoid and ghost cells. A composite odontogenic tumour: a rare case report and review of the literature. Oral Surg. 2011;4:77-81. DOI: 10.1111/j.1752-248X.2010.01109.x
Ide F, Mishima K, Saito I, Kusama K. Diagnostically challenging epithelial odontogenic tumors: A selective review of 7 jawbone lesions. Head Neck Pathol. 2009;3:18-26. DOI: 10.1007/s12105-009-0107-4
Evans BL, Carr RF, Phillipe LJ. Adenoid ameloblastoma with dentinoid: A case report. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2004;98:583-8. DOI: 10.1016/S1079210404001866
Matsumoto Y, Mizoue K, Seto K. Atypical plexiform ameloblastoma with dentinoid: Adenoid ameloblastoma with dentinoid. J Oral Pathol Med. 2001;30:251-4. DOI: 10.1034/j.1600-0714.2001.300410.x
Rai HK, Pai SM, Dayakar A, Supriya H. Adenoid ameloblastoma with dentinoid: A rare hybrid variant. J Oral Maxillofac Pathol. 2017;21:319. DOI: 10.4103/jomfp.JOMFP_53_15
Yamazaki M, Maruyama S, Abé T, Babkair H, Fujita H, Takagi R, et al. Hybrid ameloblastoma and adenomatoid odontogenic tumor: report of a case and review of hybrid variations in the literature. Oral Surg Oral Med Oral Pathol Oral Radiol. 2014;118:e12-8. DOI: 10.1016/j.oooo.2013.08.032
Ngwenya SP, Raubenheimer EJ, Noffke CE. Internal morphology of ameloblastomas: a study of 24 resected specimens. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108:754-62. DOI: 10.1016/j.tripleo.2009.06.026
Raubenheimer EJ, van Heerden WF, Noffke CE. Infrequent clinicopathological findings in 108 ameloblastomas. J Oral Pathol Med. 1995;24:227-32. DOI: 10.1111/j.1600-0714.1995.tb01172.x
Fregnani ER, da Cruz Perez DE, de Almeida OP, Kowalski LP, Soares FA, de Abreu Alves F. Clinicopathological study and treatment outcomes of 121 cases of ameloblastomas. Int J Oral Maxillofac Surg. 2010;39:145-9. DOI: 10.1016/j.ijom.2009.11.022.
Yoon HJ, Hong SP, Lee JI, Lee SS, Hong SD. Ameloblastic carcinoma: an analysis of 6 cases with review of the literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;108(6):904-13. DOI: 10.1016/j.tripleo.2009.06.045
Reichart PA, Philipsen HP, Sonner S. Ameloblastoma: Biological profile of 3677 cases. Eur J Cancer Part B Oral Oncol. 1995;31:86-99. DOI: 10.1016/0964-1955(94)00037-5
Swasdison S, Dhanuthai K, Jainkittivong A, Philipsen HP. Adenomatoid odontogenic tumors: an analysis of 67 cases in a Thai population. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:210-5. DOI: 10.1016/j.tripleo.2007.02.020
Koneru A, Hallikeri K, Nellithady GS, Krishnapillai R, Prabhu S. Immunohistochemical expression of calretinin in ameloblastoma, adenomatoid odontogenic tumor, and keratocystic odontogenic tumor: a comparative study. Appl Immunohistochem Mol Morphol. 2014;22:762-7. DOI: 10.1097/PAI.0000000000000005
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 1969 John Lennon Silva Cunha, Juliana Batista Melo da Fonte, Maria de Fátima Batista de-Melo, Rose Nely Pereira Filho, Ricardo Luiz Cavalcanti de Albuquerque Júnior
This work is licensed under a Creative Commons Attribution 4.0 International License.