Behçet’s Disease
a systemic case with recurrent oral ulcers
DOI:
https://doi.org/10.5935/2525-5711.20160023Keywords:
Vasculitis, Oral Ulcer, Skin Ulcer, Behçet SyndromeAbstract
Behçet’s disease is a chronic multisystem inflammatory disorder of unknown etiology and characterized mainly by recurrent oral ulcers, ocular involvement, genital ulcers, and skin lesions, presenting with remissions and exacerbations. Case report: The case report presents a patient with recurrent oral ulcers history and extracutaneous ulcers to 10 years who was diagnosed as having Behçet’s disease and was successfully treated. Discussion: Although complications involving the gastrointestinal, cardiovascular, renal, pulmonary, urological, artery, and central nervous system can be observed, some patients can remain asymptomatic for a long period after the diagnosis. Conclusion: This report emphasises that systemic diseases, including Behçet’s disease, can have variable presentations and can be frequently misdiagnosed.
References
Kokturk A. Clinical and pathological manifestations with differential diagnosis in Behçet’s disease. Patholog Res Int, 2012;2012:1-9.
Marshall SE. Behcet’s disease. Best Pract Res Clin Rheumatol. 2004;18:291-311.
Saadoun D, Wechsler B. Behçet’s disease. Orphanet J Rare Dis, 2012;7(1):20.
Keogan MT. Clinical Immunology Review Series: An approach to the patient with recurrent orogenital ulceration, including Behçet’s syndrome. Clin Exp Immunol, 2009;156(1):1-11.
Cho S Bin, Cho S, Bang D. New insights in the clinical understanding of behçet’s disease. Yonsei Med J, 2012;53(1):35-42.
Ranginwala A, Chalishazar M, Panja P, Buddhdev K, Kale H. Oral discoid lupus erythematosus: A study of twenty-one cases. J Oral Maxillofac Pathol, 2012;16(3):368.
Jennette JC. Overview of the 2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Clin Exp Nephrol, 2013;17(5):603-606.
Eglin RP, Lehner T, Subak-Sharpe JH. Detection of RNA complementary to herpes-simplex virus in mononuclear cells from patients with Behcet’s syndrome and recurrent oral ulcers. Lancet, 1982;2:1356-1361.
Kaneko F, Togashi A, Nomura E, Nakamura K. A new diagnostic way for Behcet’s disease: skin prick with self-saliva. Genet Res Int, 2014;2014:581468.
Akman A, Sallakci N, Kacaroglu H, Tosun O, Yavuzer U, Alpsoy E, et al. Relationship between periodontal findings and the TNF-alpha Gene 1031T/C polymorphism in Turkish patients with Behçet’s disease. J Eur Acad Dermatol Venereol, 2008;22:950-957.
Hughes T, Coit P, Adler A, Yilmaz V, Aksu K, Duzgun N, et al. Identification of multiple independent susceptibility loci in the HLA region in Behçet’s disease. Nat Genet, 2013;45:319-324.
Fei Y, Webb R, Cobb BL, Direskeneli H, Saruhan-Direskeneli G, Sawalha AH. Identification of novel genetic susceptibility loci for Behcet’s disease using a genome-wide association study. Arthritis Res Ther, 2009;11:R66.
Alpsoy E. New evidence-based treatment approach in behçet’s disease. Patholog Res Int, 2012;2012:1-11.
Hatemi G, Silman A, Bang D, Bodaghi B, Chamberlain AM, Gul A, et al. EULAR recommendations for the management of Behçet disease. Ann Rheum Dis, 2008;67:1656-1662.
Davatchi F, Sadeghi Abdollahi B, Tehrani Banihashemi A, Shahram F, Nadji A, Shams H, et al. Colchicine versus placebo in Behçet’s disease: randomized, double-blind, controlled crossover trial. Mod Rheumatol, 2009;19(5):542-549.
