The efficacy of photodynamic therapy for herpes simplex lesions in immunocompetent and oncologic individuals
DOI:
https://doi.org/10.5935/2525-5711.20220214Keywords:
Herpes Simplex, Photochemotherapy, Hematologic NeoplasmsAbstract
Aims: To investigate the efficacy of antibacterial photodynamic therapy (APDT) for the treatment of herpes simplex oral and perioral lesions in immunocompetent and oncologic individuals. Methods and Results: APDT was applied in G1 (immunocompetent, n=26) and G3 (oncologic, n=6) with methylene blue 0.01% followed by 660ηm low level LASER in all the lesion area. In G2, immunocompetent patients received Acyclovir cream 50mg/g prescription. Lesion stage, size, edema, and pain degree were obtained at the beginning of the treatment (T0), after 24 hours (T1), 48 hours (T2), 72 hours (T3), and 7 days (T4). Intra-group analyses showed significant improvement in all criteria for G1 and G3 between T0 and T4 (p<0.05), while for G2 no differences were found in lesion stage and pain level between study times (p>0.05). Most of G1 individuals showed crust stage in T2 and T3, while most of G3 individuals presented papule or vesicle at the same times (p<0.05); and G2 presented higher scores of edema in T2 than G1 and G3 at the same time (p<0.05). Conclusions: It is possible to conclude that APDT is an effective adjuvant treatment for HSV oral and perioral infections in both immunocompetent and oncologic individuals.
References
Arduino PG, Porter SR. Herpes simplex virus type 1 infection: overview on relevant clinico-pathological features. J Oral Pathol Med. 2008 Feb;37(2):107-21.
Quinn JP, Dalziel RG, Nash AA. Herpes virus latency in sensory ganglia--a comparison with endogenous neuronal gene expression. Prog Neurobiol. 2000 Feb;60(2):167-79.
Looker KJ, Magaret AS, May MT, Turner KM, Vickerman P, Gottlieb SL, et al. Global and regional estimates of prevalent and incident herpes simplex virus type 1 infections in 2012. PloS One. 2015 Oct;10(10):e0140765.
Montgomery MT, Redding SW, LeMaistre CF. The incidence of oral herpes simplex virus infection in patients undergoing cancer chemotherapy. Oral Surg Oral Med Oral Pathol. 1986 Mar;61(3):238-42.
Schubert MM, Peterson DE, Flournoy N, Meyers JD, Truelove EL. Oral and pharyngeal herpes simplex virus infection after allogeneic bone marrow transplantation: analysis of factors associated with infection. Oral Surg Oral Med Oral Pathol. 1990 Sep;70(3):286-93.
Whitley R, Baines J. Clinical management of herpes simplex virus infections: past, present, and future. F1000Res. 2018 Oct;7:1726.
Elad S, Ranna V, Ariyawardana A, Correa MEP, Tilly V, Nair RG, et al. A systematic review of oral herpetic viral infections in cancer patients: commonly used outcome measures and interventions. Support Care Cancer 2017;25:687-700.
Bacon TH, Levin MJ, Leary JJ, Sarisky RT, Sutton D. Herpes simplex virus resistance to acyclovir and penciclovir after two decades of antiviral therapy. Clin Microbiol Rev. 2003 Jan;16(1):114-28.
Piret J, Boivin G. Resistance of herpes simplex viruses to nucleoside analogues: mechanisms, prevalence, and management. Antimicrob Agents Chemother. 2011 Feb;55(2):459-72.
Eduardo CP, Aranha AC, Simões A, Bello-Silva MS, Ramalho KM, Esteves-Oliveira M, et al. Laser treatment of recurrent herpes labialis: a literature review. Lasers Med Sci. 2014;29:1517-29.
Oniszczuk A, Wojtunik-Kulesza KA, Oniszczuk T, Kasprzak K. The potential of photodynamic therapy (PDT)-Experimental investigations and clinical use. Biomed Pharmacother. 2016 Oct;83:912-29.
Yildirim C, Karaarslan ES, Ozsevik S, Zer Y, Sari T, Usumez A. Antimicrobial efficiency of photodynamic therapy with different irradiation durations. Eur J Dent. 2013 Oct;7(4):469-73.
Javed F, Samaranayake LP, Romanos GE. Treatment of oral fungal infections using antimicrobial photodynamic therapy: a systematic review of currently available evidence. Photochem Photobiol Sci. 2014;13(5):726-34.
Simões A, Campos L, Freitas PM, Paula C. Laser as a therapy for oral complications induced by chemotherapy and radiotherapy. J Bras Laser. 2009 Jan;2(10):18-23.
Rocha BA, Melo Filho MR, Simões A. Antimicrobial photodynamic therapy to treat chemotherapy-induced oral lesions: report of three cases. Photodiagnosis Photodyn Ther. 2016 Mar;13:350-2.
Ramalho KM, Cunha SR, Gonçalves F, Escudeiro GS, Steiner-Oliveira C, Horliana ACRT, et al. Photodynamic therapy and Acyclovir in the treatment of recurrent hers labialis: a controlled randomized clinical trial. Photodiagnosis Photodyn Ther. 2021 Mar;33:102093.
Ajmal M. Effectiveness of photodynamic therapy as an adjunct to topical antiviral therapy in the treatment of herpes labialis: a randomized controlled clinical trial. Photodiagnosis Photodyn Ther. 2021 Jun;34:102302.
Carvalho RR, Eduardo FP, Ramalho KM, Antunes JLF, Bezinelli LM, Magalhães MHCG, et al. Effect of laser phototherapy on recurring herpes labialis prevention: an in vivo study. Lasers Med Sci. 2010 May;25(3):397-402.
Carvalho CG, Medeiros-Filho JB, Ferreira MC. Guide for health professionals addressing oral care for individuals in oncological treatment based on scientific evidence. Support Care Cancer. 2018 Aug;26(8):2651-61.
Elad S, Zadik Y, Hewson I, Hovan A, Correa MEP, Logan R, et al. A systematic review of viral infections associated with oral involvement in cancer patients: a spotlight on Herpesviridea. Support Care Cancer. 2010 Aug;18(8):993-1006.
Sandherr M, Hentrich M, Von Lilienfeld-Toal M, Massenkeil G, Neumann S, Penack O, et al. Antiviral prophylaxis in patients with solid tumours and haematological malignancies--update of the Guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society for Hematology and Medical Oncology (DGHO). Ann Hematol. 2015 Sep;94(9):1441-50.
Walsh LJ. Clinical assessment and management of the oral environment in the oncology patient. Aust Dent J. 2010 Jun;55(Suppl 1):66-77.
Warkentin DI, Epstein JB, Campbell LM, Yip JG, Cox VC, Ransier A, et al. Valacyclovir versus acyclovir for HSV prophylaxisin neutropenic patients. Ann Pharmacother. 2002 Oct;36(10):1525-31.
Marotti J, Aranha AC, Eduardo CP, Ribeiro MS. Photodynamic therapy can be effective as a treatment for herpes simplex labialis. Photomed Laser Surg. 2009 Apr;27(2):357-63.
Ramalho KM, Rocha RG, Correa-Aranha AC, Cunha SRB, Simões A, Campos L, et al. Treatment of herpes simplex labialis in macule and vesicle phases with photodynamic therapy. Report of two cases. Photodiagnosis Photodyn Ther. 2015;12(2):321-3.
Osiecka BJ, Nockowski P, Kwiatkowski S, Szepietowski JC. Photodynamic therapy with red light and 5-aminolaevulinic acid for herpes simplex recurrence: preliminary results. Acta Derm Venereol. 2017 Nov;97(10):1239-40.
Bergmann OJ, Mogensen SC, Ellegaard J. Herpes simplex virus and intraoral ulcers in immunocompromised patients with haematologic malignancies. Eur J Clin Microbiol Infect Dis. 1990 Mar;9(3):184-90.
Emmanouilides C, Glaspy J. Opportunistic infections in oncologic patients. Hematol Oncol Clin North Am. 1996 Aug;10(4):841-60.
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Copyright (c) 2022 Fernanda W Mello, Taimara Mariani, Mariah L Lisboa, Giovanna S Durigon, Alessandra R Camargo, Etiene A Munhoz
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