Ethical, clinical and technical analysis of face transplantation

Authors

  • Matheus França Lourenço Universidade de São Paulo https://orcid.org/0000-0001-8742-1024
  • Juliana Maria Anton Universidade Federal de São Paulo
  • Larissa Izumi Fujii Universidade Federal de São Paulo
  • Isabela Ormond Cesar Laranjeira Universidade de Cuiabá
  • Julia Falarini Universidade Nove de Julho
  • Aline Cristina Ormond Granja Universidade Estadual Paulista
  • Débora Teresa da Silva Ormond Universidade Federal de Juiz de Fora
  • Cícero Dayves da Silva Bezerra Universidade Nove de Julho
  • Flávio Carneiro Hojaij Universidade de São Paulo

Keywords:

Face transplantation, Bioethics, “Surgical Procedures, Operative”, “Elective Surgical Procedures”, “Contraindications, Procedure.”

Abstract

Introduction: Face transplants constitute a new reality in reconstructive surgery, allowing a new perspective on the restoration of complex facial defects and the possible complications resulting from this procedure. Methods: The purpose of this work is to perform a bibliographic review on the techniques used to perform face transplantation, their difficulties of execution, possible post-operative clinical repercussions and the bioethics of face transplantation. Results: Since 2005 more than 30 face transplants have been performed in the world, the patients submitted to this procedure showed a good sensory recovery, successful motor and functional recovery slower and variable. Regarding the aesthetic and psychological issues, all patients have reported improvements. However, acute rejection is common to solid organ transplants and allograft, while chronic rejection has not been reported in even one face transplant case. Discussion: One of the controversial aspects of face transplantation is that it is a high-risk procedure for a non-life threatening condition; lifelong use of immunosuppressants; and complications affecting the individual after transplantation. Conclusion: Therefore, face transplantation presents itself as a therapeutic option, which applies to a very limited number of patients, in which conventional reconstructive techniques have not been successful, which have brought functional, psychological and social comorbidities to the transplanted patient.

Author Biographies

Matheus França Lourenço, Universidade de São Paulo

Faculdade de Medicina da Universidade de São Paulo (FMUSP), LIM/02 Laboratório de Anatomia e Cirurgia Vascular

Juliana Maria Anton, Universidade Federal de São Paulo

Cirurgia Cabeça e Pescoço

Larissa Izumi Fujii, Universidade Federal de São Paulo

Cirurgia Cabeça e Pescoço

Isabela Ormond Cesar Laranjeira, Universidade de Cuiabá

Farmacologia

Aline Cristina Ormond Granja, Universidade Estadual Paulista

Odontologia

Débora Teresa da Silva Ormond, Universidade Federal de Juiz de Fora

Dermatologia

Flávio Carneiro Hojaij, Universidade de São Paulo

Faculdade de Medicina da Universidade de São Paulo (FMUSP), LIM/02 Laboratório de Anatomia e Cirurgia Vascular

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Published

2020-01-11

How to Cite

1.
Lourenço MF, Anton JM, Fujii LI, Laranjeira IOC, Falarini J, Granja ACO, et al. Ethical, clinical and technical analysis of face transplantation. J Oral Diagn [Internet]. 2020 Jan. 11 [cited 2024 Sep. 19];5:1-6. Available from: https://jordi.com.br/revista/article/view/76

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Section

Review Article