Tuberculosis

Primary Diagnosis From an Oral Ulcer

Authors

  • Bruno Teixeira Gonçalves Rodrigues Rio de Janeiro State University https://orcid.org/0000-0002-3115-3216
  • Alexandre de Freitas Caetano Guimarães Rio de Janeiro State University
  • Fábio Ramôa Pires Rio de Janeiro State University
  • Mônica Simões Israel Rio de Janeiro State University

DOI:

https://doi.org/10.5935/2525-5711.20200025

Keywords:

Tuberculosis, Oral Ulcer, Tongue, Mycobacterium tuberculosis

Abstract

Tuberculosis (TB) is a contagious chronic disease caused by Mycobacterium tuberculo- sis. Tuberculosis can manifest within the oral cavity as a painless chronic ulcer - which resembles several other oral diseases - at this moment, diagnosis can be achieved through an incisional biopsy. We report a case of TB diagnosed from an oral ulcer in a 54-year- -old male referred for evaluation of a 1-month lasting non-healing ulcer in the tongue. Intraoral clinical examination revealed a single painless chronic ulcer with irregular borders located in the apex of the tongue. Squamous cell carcinoma was the main clinical diagnosis; however, after performing an incisional biopsy and histopathological exami- nation, TB was suggested, and confirmed through the purified protein derivative (PPD) skin test. Patient was then referred to a medical service and confirmed lung involvement by the disease, starting the treatment protocol for TB. A 1-month follow-up showed complete regression of the oral lesion. The patient completed the TB treatment and is under clinical follow-up for 2 years.

Author Biographies

Bruno Teixeira Gonçalves Rodrigues, Rio de Janeiro State University

 Department of Diagnosis and Therapeutics

Alexandre de Freitas Caetano Guimarães, Rio de Janeiro State University

Department of Diagnosis and Therapeutics

Fábio Ramôa Pires, Rio de Janeiro State University

Department of Diagnosis and Therapeutics

Mônica Simões Israel, Rio de Janeiro State University

Department of Diagnosis and Therapeutics

References

Pinto ASB, Furuse C, Soares HA, Thomaz LA, Teixeira LN. Simultaneous oral, bone, and lung manifestations of tuberculosis. J Oral Diag. 2017;2(1):e20170033.

World Health Organization (WHO). Global tuberculosis report 2019 [Internet]. Geneva: WHO; 2019; [access in 2020 Jul 07]. Available from: https://apps.who.int/iris/bitstream/handle/10665/329368/9789241565714-eng.pdf?ua=1/

Arora KS, Garg S, Kaur P, Mohapatra S. Primary oral tuberculosis on the tongue mimicking squamous cell carcinoma. Indian J Tuberc. 2018 Jan;65(1):84-6.

Ju W, Fu Y, Liu Y, Tan Y, Dong M, Wang L, et al. Clinical and pathologic analyses of tuberculosis in the oral cavity: report of 11 cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Jan;125(1):44-51.

Jain P, Jain I. Oral manifestations of tuberculosis: step towards early diagnosis. J Clin Diagn Res. 2014 Dec;8(12):ZE18-ZE21.

Nagaraj V, Sashykumar S, Viswanathan S, Kumar S. Multiple oral ulcers leading to diagnosis of pulmonary tuberculosis. Eur J Dent. 2013 Apr/Jun;7(2):243-5.

Hale RG, Tucker DI. Head and neck manifestations of tuberculosis. Oral Maxillofac Surg Clin North Am. 2008;20:635-42.

Ryan GJ, Shapiro HM, Lenaerts AJ. Improving acid-fast fluorescent staining for the detection of mycobacteria using a new nucleic acid staining approach. Tuberculosis (Edinb). 2014 Sep;94(5):511-8.

Souza BC, Lemos VMA, Munerato MC. Oral manifestation of tuberculosis: a case-report. Braz J Infect Dis. 2016;20(2):210-3.

González-Martín J, García-García JM, Anibarro L, Vidal R, Esteban J, Blanquer R, et al. Consensus document on the diagnosis, treatment and prevention of tuberculosis. Arch Bronconeumol. 2010 May;46(5):255-74.

Salian NV, Rish JA, Eisenach KD, Cave MD, Bates JH. Polymerase chain reaction to detect Mycobacterium tuberculosis in histologic specimens. Am J Respir Crit Care Med. 1998 Oct;158(4):1150-5.

Sacchettini JC, Rubin EJ, Freundlich JS. Drugs versus bugs: in pursuit of the persistent predator Mycobacterium tuberculosis. Nat Rev Microbiol. 2008 Jan;6(1):41-52.

Alsultan A, Peloquin CA. Therapeutic drug monitoring in the treatment of tuberculosis: an update. Drugs. 2014 Jun;74(8):839-54.

Sierra C, Fortun J, Barros C, Melcon E, Condes E, Cobo J, et al. Extra-laryngeal head and neck tuberculosis. Clin Microbiol Infect. 2000 Dec;6(12):644-8.

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Published

2020-01-11

How to Cite

1.
Rodrigues BTG, Guimarães A de FC, Pires FR, Israel MS. Tuberculosis: Primary Diagnosis From an Oral Ulcer. J Oral Diagn [Internet]. 2020 Jan. 11 [cited 2024 Sep. 19];5:1-4. Available from: https://jordi.com.br/revista/article/view/90

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Section

Original Article