Myofibroma of the oral cavity mimicking a non-neoplastic inflammatory process
an unusual report
DOI:
https://doi.org/10.5935/2525-5711.20200002Keywords:
myofibroma, oral cavity, oral pathology, immunohistochemistryAbstract
Myofibroma is a rare condition that is a benign neoplasm characterized by the proliferation of fusiform cells originated from myofibroblasts. A 9-year-old male patient presented a intraosseous lesion in the oral cavity, which caused mobility in two teeth within appro- ximately 1 month and was submitted to excisional biopsy. Microscopic analysis revealed fragments of neoplasia of mesenchymal origin, characterized by proliferation of spindle cells with eosinophilic staining, showing loose chromatin and indistinct cytoplasmic boundaries, as well as cells with vacuolated cytoplasm. The lesion was very cellular and organized into a bundle of intersecting neoplastic cells. In the immunohistochemical analysis, the proliferative index evaluated for the Ki-67 antibody was below 5%. Neoplas- tic cells were strongly positive for the smooth muscle actin antibody. Rare mitoses were observed in the specimen, leading to the diagnosis of myofibroma. After the diagnosis, the patient was referred to his pediatrician for investigation of possible myofibromatosis. After clinical and imaging analysis, no similar lesions were found, and the diagnosis of myofibromatosis was excluded. At 6 months postoperative, the patient returned to the outpatient clinic, without clinical and radiographic signs of recurrence and buccal tissues with normal appearance.
References
Nirvikalpa N, Narayanan V. Intra-osseous infantile myofibroma of the mandible-a case report. J Oral Maxillofac Surg Med Pathol. 2012 May;24(2):128-31.
Fushimi K, Shiiba M, Kouzu Y, Kasama H, Higo M, Koike H, et al. Central myofibroma of the maxilla: a case report. J Oral Maxillofac Surg Med Pathol. 2015;27(1):78-83.
Nashef R, Fleissig Y, Abu-Tair J, Heyman O, Doviner V. Solitary central myofibroma of the maxilla: a case report. J Oral Maxillofac Surg Med Pathol. 2014 Oct;26(4):558-62.
Brierley DJ, Khurram SA, Speight PM. Solitary myofibroma of the adult mandible: a case report. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013 Mar;115(3):e40-e3.
Venkatesh V, Kumar BP, Kumar KA, Mohan AP. Myofibroma-a rare entity with unique clinical presentation. J Maxillofac Oral Surg. 2015 Mar;14(Suppl 1):64-8.
Dhupar A, Carvalho K, Sawant P, Spadigam A, Syed S. Solitary intra-osseous myofibroma of the jaw: a case report and review of literature. Children (Basel). 2017 Oct;4(10):91.
Demo PG, Savoini M, Marchetti M, Maletta F, Zavattero E, Ramieri G. Surgical management of myofibroma of the gengiva. J Craniofac Surg. 2016 Oct;27(7):e646-e8.
Castro HHO, Gomes HE, Tassara LFR, Freitas JB, Grandinetti HAM, Capistrano HM. Myofibroma of the mandible-case report. Pediatr Dent J. 2016;26(1):38-41.
Chattaraj M, Gayen S, Chatterjee RP, Shah N, Kundu S. Solitary myofibroma of the mandible in a six-year old-child: diagnosis of a rare lesion. J Clin Diagn Res. 2017 Apr;11(4):ZD13-ZD15.
Foss RD, Ellis GL. Myofibromas and myofibromatosis of the oral region: a clinicopathologic analysis of 79 cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2000 Jan;89(1):57-65.
Allon I, Vered M, Buchner A, Dayan D. Central (intraosseous) myofibroma of the mandible: clinical, radiologic, and histopathologic features of a rare lesion. Oral Surg Oral Med Oral Pathol Oral Radiol Endodontol. 2007 Apr;103(4):e45-e53.
Smith MH, Reith JD, Cohen DM, Islam NM, Sibille KT, Bhattacharyya I. An update on myofibromas and myofibromatosis affecting the oral regions with report of 24 new cases. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017 Jul;124(1):62-75.
Sundaravel S, Anuthama K, Prasad H, Sherlin HJ, Ilayaraja V. Intraosseous myofibroma of mandible: a rarity of jaws: with clinical, radiological, histopathological and immunohistochemical features. J Oral Maxillofac Pathol. 2013;17(1):121-5.
Narayen V, Ahmed SA, Suri C, Tanveer S. Myofibroma of the gingiva: a rare case report and literature review. Case Rep Dent. 2015 Mar;2015:243894.
Vered M, Allon I, Buchner A, Dayan D. Clinico-pathologic correlations of myofibroblastic tumors of the oral cavity. II. Myofibroma and myofibromatosis of the oral soft tissues. J Oral Pathol Med. 2007 May;36(5):304-14.
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Copyright (c) 1969 Éwerton Daniel Rocha Rodrigues, Eder Magno Ferreira de Oliveira, Renato da Costa Ribeiro, Fabricio Passador-Santos, Felipe Rodrigues de Matos, Gustavo Almeida Souza
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