Clinicopathological study of sialolithiasis
a retrospective analysis of 11 cases
DOI:
https://doi.org/10.5935/2525-5711.20190006Keywords:
Salivary gland calculi, Submandibular gland, Pathology, DiagnosisAbstract
Oral squamous cell carcinoma (OSCC) is one of the most common cancers and presents the highest mortality rate of head and neck tumours. The aim of this study was to eva- luate the clinical and histological features of patients with OSCC in Florianópolis, Santa Catarina, Brazil between 2006 and 2016. Demographic and clinical characteristics such as age, gender, tobacco and alcohol consumption, anatomical site, clinical stage, and tre- atment were retrospectively collected from histopathological and medical reports. Of 196 patients with OSCC, 82.14% were male with a mean age of 58.28±10.45 years. Tobacco and alcohol consumption was reported in 88.76% and 75.9% of patients, respectively. The tongue was the anatomical site most affected (25.13%) and ulcers were the most prevalent clinical aspect (95.21%). A total of 103 (52.55%) patients were diagnosed with advanced stage (III/IV). Regarding treatment, 59.24% received more than one type of therapy, while 39.67% were treated exclusively with surgery. Regarding histological differentiation, 72.9% of the cases were moderately/poorly differentiated, 23.8% had vascular invasion, 17.9% had lymphatic invasion, and perineural invasion was observed in 29.5% of the patients. The survival rate showed a worse prognosis for patients diagnosed at stage III/ IV and the primary tumour was located in the inferior level of the mouth in 80% of these cases. The results showed that the majority of cases were diagnosed at an advanced stage, compromising treatment and prognosis. Educational and preventive measures should be improved in an effort to allow for early diagnosis.
References
Marchal F, Dulguerov P. Sialolithiasis management: the state of the art. Arch Otolaryngol Head Neck Surg. 2003; 129(9):951-6.
Kopeć T, Wierzbicka M, Kałużny J, Młodkowska A, Szyfter W. Sialendoscopy and sialendoscopically-assisted operations in the treatment of lithiasis of the submandibular and parotid glands: our experience of 239 cases. Br J Oral Maxillofac Surg. 2016; 54(7):767-71.
Sherman JA, Mcgurk M. Lack of correlation between water hardness and salivary calculi in England. Br J Oral Maxillofac Surg.2000; 38:50-53.
Brazao-Silva MT, Prosdocimi FC, Lemos-Junior CA, de Sousa SO. Clinicopathological aspects of 25 cases of sialolithiasis of minor salivary glands. Gen Dent. 2015; 63(3):e22-6.
Buckenham T.Salivary duct intervention. Semin InterventRadiol. 2004; 21: 143-148.
Ngu RK, Brown JE, Whaites EJ, et al.Salivary duct strictures: nature and incidence in benign salivary obstruction. Dentomaxillofac Radiol.2007; 36:63Y67.
Jadu FL. The mystery of meal time swellings revealed. Oral Health. 2014; 104: 33-35.
Alcure ML, Della Coletta R, Graner E, Di Hipolito O Jr, Lopes MA. Sialolithiasis of minor salivary glands: a clinical and histopathological study. Gen Dent.2005; 53(4):278-81.
Rzymska-Grala I, Stopa Z, Grala B, Gołębiowski M, Wanyura H, Zuchowska A, Sawicka M, Zmorzyński M. Salivary gland calculi - contemporary methods of imaging. Pol J Radiol.2010; 75(3):25-37.
Strychowsky JE, Sommer DD, Gupta MK, Cohen N, Nahlieli O. Sialendoscopy for the management of obstructive salivar gland disease: a systematic review and meta-analysis. Arch
Otolaryngol Head Neck Surg.2012;138:541-547.
Anneroth G, Hansen LS. Minor salivary gland calculi. A clinical and histopathological study of 49 cases. Int J Oral Surg.1983; 12:80-89.
Schroeder S A, Homoe P Wagner N, Bardow A. Does saliva composition affect the formation of sialolithiasis? J Laryngol Otol. 2016; 15:1-6.
Karengera D. Yousefpour A, Sadeghi H.M, Reychler H. Sialolithiasis in children as a diagnostic dilemma, Eur. Arch. Otorhinolaryngol.2000; 257:161-163.
Souza IF, Kawatake MM, Soares AB, Moraes PC, Araújo VC, Passador-Santos F. Sialolithiasis of minor salivary glands. RGO - Rev Gaúcha Odontol. 2015; 63(1):63-68.
Lazaridou M, Iliopoulos C, Antoniades K, Tilaveridis I, Dimitrakopoulos I, Lazaridis N (2012) Salivary gland trauma: a review of diagnosis and treatment. Craniomaxillofac Trauma Reconstr 5(4):189-96.
Levy DM, Remine WH, Devine KD. Salivary gland calculi. Pain, swelling associated with eating. JAMA. 1962; 29(181):1115-1119.
Flaitz CM.Sialolithiasis involving the maxillary alveolar mucosa. Am J Dent.2000; 13(6):342-3
Siddiqui SJ. Sialolithiasis: an unusually large submandibular salivary stone. Br Dent J.2002; 193(2):89-9.
ullon PA, Miller AS. Sialolithiasis of accessory salivary glands: review of 55 cases. J Oral Surg.1972; 30(11):832-4
Alkurt MT, Peker I. Unusually large submandibular sialoliths: report of two cases. Eur J Dent.2009; 3(2):135-139.
Drage NA, Brown JE. Cone beam computed sialography of sialoliths. Dentomaxillofac Radiol. 2009; 38(5):301-305.
MimuraM, TanakaN, IchinoseS, KimijimaY, AmagasaT.Possible etiology of calculi formation in salivary glands: biophysical analysis of calculus. Med Mol Morphol. 2005; 38(3):189-195.
Im YG, Kook MS, Kim BG, Kim JH, Park YJ, Song HJ. Characterization ofa submandibular gland sialolith: micromorphology, crystalline structure,and chemical compositions. Oral Surg Oral Med Oral Pathol Oral Radiol.2017;124(1):e13-e20.
Seifert G. Tumor-like lesions of the salivary glands. The new WHO classification. Pathol Res Pract.1992; 188:836-846.
Harrison JD, Epivatianos A, Bhatia SN. Role of microliths in the aetiology of chronic submandibular sialadenitis: a clinicopathological investigation of 154 cases. Histopathology.1997; 31(3):237-351.
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Copyright (c) 1969 Isabele Cardoso Vieira De-Castro, Angelo Adalberto Ferreira de-Jesus, Roberto Almeida De Azevedo, Paulo Sérgio Flores Campos, Jean Nunes dos Santos
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