Necrotizing sialometaplasia

systematic review and meta analyses over the past 46 years


  • Júlia dos Santos Vianna Néri Universidade Federal da Bahia
  • Viviane Palmeira da Silva Universidade Federal da Bahia
  • Nara Santos Araújo Universidade Federal da Bahia
  • Thiago Alexsander Oliveira Gomes Centro Universitário UNIFTC
  • Mayana Barreto do Nascimento Universidade Federal da Bahia
  • Maria Cristina Teixeira Cangussu Universidade Federal da Bahia
  • Luciana Maria Pedreira Ramalho Universidade Federal da Bahia
  • Jean Nunes dos Santos Universidade Federal da Bahia



Necrotizing sialometaplasia, Salivary Glands, Diagnosis, Pathology, Oral, Evidence-Based Dentistry.


Objectives: The aim of this study was to characterize the main characteristics of this disease in relation to diagnosis, clinical aspects, progression and treatment as well as correlating them with remission time. Material and Methods: A systematic search was performed following the guidelines given by PRISMA and the Joanna Briggs Institute. PubMed, Web of Science and Scopus were the databases used. Results: The final analysis resulted in 108 articles with 173 clinical cases. The longest remission time for signs and symptoms (>7 weeks) was registered among male patients (p = 0.02) and outside the oral cavity; however no significant correlation was observed (p>0.05). A high risk of bias was the most common rating among the articles analyzed (55%); followed by moderate (27%) and low (18%). The lack of standardization in clinical case report descriptions made it difficult to gain a thorough knowledge of the essential characteristics of the NS pathological processes. Conclusion: It is recommended that publications follow the standards recommended by the literature; in addition, studies using advanced technologies to better understand NS’s pathological path are recommended so as to propose effective treatments for this disease.

Author Biographies

Júlia dos Santos Vianna Néri, Universidade Federal da Bahia

Faculdade Adventista da Bahia

Viviane Palmeira da Silva, Universidade Federal da Bahia

Escola Bahiana de Medicina e Saúde Pública. Centro Universitário UNIFTC.

Nara Santos Araújo, Universidade Federal da Bahia

Programa de Pós-graduação em Odontologia e Saúde

Mayana Barreto do Nascimento, Universidade Federal da Bahia

Programa de Pós-graduação em Odontologia e Saúde

Maria Cristina Teixeira Cangussu, Universidade Federal da Bahia

Programa de Pós-graduação em Odontologia e Saúde

Luciana Maria Pedreira Ramalho, Universidade Federal da Bahia

Programa de Pós-graduação em Odontologia e Saúde

Jean Nunes dos Santos, Universidade Federal da Bahia

Programa de Pós-graduação em Odontologia e Saúde


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How to Cite

Néri J dos SV, Silva VP da, Araújo NS, Gomes TAO, Nascimento MB do, Cangussu MCT, et al. Necrotizing sialometaplasia: systematic review and meta analyses over the past 46 years. J Oral Diag [Internet]. 2024 Jan. 28 [cited 2024 Jul. 20];9:1-10. Available from:



Review Article