Evaluation of CD57+ cells in oral squamous cells carcinoma and their relationship with clinicopathological parameters
DOI:
https://doi.org/10.5935/2525-5711.20170010Keywords:
Mouth Neoplasms, Antigens, CD57, ImmunohistochemistryAbstract
Introduction: The immune response occurring in the tumor microenvironment is very complex. Surface molecule CD57 can be expressed by natural killer cells and/or activated T lymphocytes, which are key cellular types in the cancer immunity. Objectives: This study investigated CD57 immunoexpression in immune cells of oral squamous cell carcinoma (OSCC) and verified its association with clinicopathological features. Methods: Paraffin-embedded sections of 45 OSCCs were submitted to morphological and immunohistochemical analysis using anti-CD57 antibody. Relationship between the expression of CD57 and clinicopathological parameters (age, metastasis to regional lymph nodes, clinical stage and histopathological grade of malignancy) was verified by Pearson’s Chi square, and Fisher exact statistical tests. Results: The majority (64.4%) of the OSCCs analyzed affected subjects of male gender and over 40 years old (68.9%). There was a significant association between histological grade of malignancy and presence of lymph node metastasis, as well as clinical stage (p<0.05). Conclusions: The results suggest that CD57+ cells immune cells infiltration is a consistent finding in OSCC, regardless of clinicopathological features of these tumors.
References
Türkseven MR, Oygür T. Evaluation of natural killer cell defense in oral squamous cell carcinoma. Oral Oncol. 2010;46:e34-7.
Fraga CA, de Oliveira MV, Domingos PL, Botelho AC, Guimaraes AL, Teixeira-Carvalho A, et al. Infiltrating CD57+ inflammatory cells in head and neck squamous cell carcinoma: clinicopathological analysis and prognostic significance. Appl Immunohistochem Mol Morphol. 2012;20:285-90.
dos Santos Pereira J, da Costa Miguel MC, Guedes Queiroz LM, da Silveira ÉJ. Analysis of CD8+ and CD4+ cells in oral squamous cell carcinoma and their association with lymph node metastasis and histologic grade of malignancy. Appl Immunohistochem Mol Morphol. 2014;22:200-5.
Burnet FM. Immunological Surveillance. Oxford: Pergamon Press. 1970; p. 240-1.
Zancope E, Costa NL, Junqueira-Kipnis AP, Valadares MC, Silva TA, Leles CR, et al. Differential infiltration of CD8+ and NK cells in lip and oral cavity squamous cell carcinoma. J Oral Pathol Med. 2010;39:162-7.
Nielsen CM, White MJ, Goodier MR, Riley EM. Functional significance of CD57 expression on human NK Cells and Relevance to Disease. Front Immunol. 2013;4:422.
Kared H, Martelli S, Ng TP, Pender SL, Larbi A. CD57 in human natural killer cells and T-lymphocytes. Cancer Immunol Immunother. 2016;65:441-52.
Lopez-Vergès S, Milush JM, Pandey S, York VA, Arakawa-Hoyt J, Pircher H, et al. CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset. Blood. 2010;116:3865-74.
Batista MD, Tincati C, Milush JM, Ho EL, Ndhlovu LC, York VA, et al. CD57 expression and cytokine production by T cells in lesional and unaffected skin from patients with psoriasis. PLoS One. 2013;8:e52144.
Ishigami S, Natsugoe S, Tokuda K, Nakajo A, Xiangming C, Iwashige H, et al. Clinical impact of intratumoral natural killer cell and dendritic cell infiltration in gastric cancer. Cancer Lett. 2000;59:103-8.
Chaput N, Svrcek M, Aupérin A, Locher C, Drusch F, Malka D, et al. Tumour-infiltrating CD68+ and CD57+ cells predict patient outcome in stage II-III colorectal cancer. Br J Cancer. 2013;109:1013-22.
Taghavi N, Bagheri S, Akbarzadeh A. Prognostic implication of CD57, CD16, and TGF-β expression in oral squamous cell carcinoma. J Oral Pathol Med. 2016;45:58-62.
Bryne M. Is the invasive front of an oral carcinoma the most important area for prognostication? Oral Dis. 1998;4:70-7.
Silveira EJ, Godoy GP, Lins RD, Arruda Mde L, Ramos CC, Freitas Rde A, et al. Correlation of clinical, histological, and cytokeratin profiles of squamous cell carcinoma of the oral tongue with prognosis. Int J Surg Pathol. 2007;15:376-83.
Dissanayaka WL, Pitiyage G, Kumarasiri PV, Liyanage RL, Dias KD, Tilakaratne WM. Clinical and histopathologic parameters in survival of oral squamous cell carcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;113:518-25.
Majchrzak E, Szybiak B, Wegner A, Pienkowski P, Pazdrowski J, Luczewski L, et al. Oral cavity and oropharyngeal squamous cell carcinoma in young adults: a review of the literature. Radiol Oncol. 2014;48:1-10.
Scully C, Bagan J. Oral squamous cell carcinoma: overview of current understanding of a etiopathogenesis and clinical implications. Oral Dis. 2009;15:388-99.
Sturgis EM, Cinciripini PM. Trends in head and neck cancer incidence in relation to smoking prevalence: an emerging epidemic of human papillomavirus-associated cancers? Cancer. 2007;110:1429-35.
Iida M, Takayama E, Naganawa K, Mitsudo K, Adachi M, Baba J, et al. Increase of peripheral blood CD57+ T-cells in patients with oral squamous cell carcinoma. Anticancer Res. 2014;34:5729-34.
Köhler HF, Kowalski LP. Prognostic impact of the level of neck metastasis in oral cancer patients. Braz J Otorhinolaryngol. 2012;78:15-20.
Montebugnoli L, Gissi DB, Flamminio F, Gentile L, Dallera V, Leonardi E, et al. Clinicopathologic parameters related to recurrence and locoregional metastasis in 180 oral squamous cell carcinomas. Int J Surg Pathol. 2014;22:55-62.
Costa Ade L, Araújo Júnior RF, Ramos CC. Correlation between TNM classification and malignancy histological feature of oral squamous cell carcinoma. Braz J Otorhinolaryngol. 2005;71:181-7.
Whiteside TL. Tricks tumors use to escape from immune control. Oral Oncol. 2009;45:e119-23.
Ponnappan S, Ponnappan U. Aging and immune function: molecular mechanisms to interventions. Antioxid Redox Signal. 2011;14:1551-85.
Vivier E, Ugolini U, Blaise D, Chabannon C, Brossay L. Targeting natural killer cells and natural killer T cells in cancer. Nat Rev Immunol. 2012;12:239-52.
Vesely MD, Kershaw MH, Schreiber RD, Smyth MJ. Natural innate and adaptive immunity to cancer. Annu Rev Immunol. 2011;29:235-71.
da Silveira EJ, Miguel MC, Lima KC, Freitas Rde A, de Morais Mde L, Queiroz LM. Analysis of local immunity in squamous cell carcinoma of the tongue and lower lip. Exp Mol Pathol. 2010;88:171-5.
Strioga M, Pasukoniene V, Characiejus D. CD8+ CD28- and CD8+ CD57+ T cells and their role in health and disease. Immunology. 2011;134:17-32.
Donskov F, von der Maase H. Impact of immune parameters on long-term survival in metastatic renal cell carcinoma. J Clin Oncol. 2006;24:1997-2005.
Serrano D, Monteiro J, Allen SL, Kolitz J, Schulman P, Lichtman SM, et al. Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia. J Immunol. 1997;158:1482-9.
