Eight-year follow-up of central giant cell lesion treated with corticosteroid
Case report
DOI:
https://doi.org/10.5935/2525-5711.20170031Palabras clave:
Granuloma, Giant Cell, Triamcinolone Acetonide, Drug Therapy, Pathology, OralResumen
Introduction: Central giant-cell granulomas (CGCL) are benign, but occasionally ag- gressive, lesions that traditionally have been treated surgically. Nonsurgical treatments, such as intralesional corticosteroid injections, systemic calcitonin and interferon have been reported. The advantages of this therapy include its less-invasive nature, the pro- bable lower cost to the patient and the preservation of important structures. Objectives: This paper aims to report a case of a pediatric patient with CGCL of the jaw, which was successfully treated with intralesional corticosteroid injections as it’s only therapy and discuss if there is an ideal waiting period between nonoperative treatment and the need for surgical intervention. Methods and Materials: an eight-year-old boy with a central giant cell lesion on the right side of the mandible was treated with intralesional corticos- teroids injections. Results and Conclusion: After an eight-year follow-up, the patient’s bony architecture was near normal. The panoramic radiography showed areas of new bone formation and neither recurrence nor side effects of the medication have been also detected. Is there an ideal waiting period between nonoperative treatment and the need for surgical intervention? It is estimated that a monitoring period of 6-8 years is necessary to determine the success of such treatment.
Citas
Bataineh AB, AI-Khateeb T, Rawashdeh MA. The surgical treatment of central giant cell granuloma of the mandible. J Oral Maxillofac Surg. 2002;60:756-61.
De Lange J, Van den Akker HP. Clinical and radiological features of central giant-cell lesions of the jaw. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2005;99:464-70.
de Lange J, van den Akker HP, van den Berg H. Central giant cell granuloma of the jaw: a review of the literature with emphasis on therapy options. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007;104:603-15.
Chuong R, Kaban LB, Kozakewich H, Perez-Atayde A. Central giant cell lesions of the jaws: a clinicopathologic study. J Oral Maxillofac Surg. 1986;44:708-13.
Nicolai G, Lorè B, Mariani G, Bollero P, de Marinis L, Calabrese L. Central giant cell granuloma of the jaws. J Craniofac Surg. 2010;21:383-6.
Nogueira RLM, Teixeira RC, Cavalcante RB, Ribeiros RA, Rabenhosr SH. Intralesional injection of triamcinolone hexacetonide as an alternative treatment for central giant-cell granuloma in 21 cases. Int J Oral Maxillofac Surg. 2010;39:1204-10.
Jacoway JR, Howell FV, Terry BC. Central giant cell granuloma: an alternative to surgical therapy. Oral Surg Oral Med Oral Pathol. 1988;66:572.
Sezer B, Koyuncu B, Gomel M, Günbay, T. Intralesional corticosteroid injection for central giant cell granuloma: a case report and review of the literature. Turk J Pediatr. 2005;47:75-81.
Carlos R, Sedano HO. Intralesional corticosteroids as an alternative treatment for central giant cell granuloma. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002;93:161-6.
Mohanty S, Jhamb A. Central giant cell lesion of mandible managed by intralesional triamcinolone injections. A report of two cases and literature review. Med Oral Patol Oral Cir Bucal. 2009;14:E98-102.
Wendt FP, Torriani MA, Gomes AP, de Araujo LM, Torriani DD. Intralesional corticosteroid injection for central giant cell granuloma: an alternative treatment for children. J Dent Child (Chic). 2009;76:229-32.
Rachmiel A, Emodi O, Sabo E, Aizenbud D, Peled M. Combined treatment of aggressive central giant cell granuloma in the lower jaw. J Craniomaxillofac Surg. 2012;40:292-7.
