Extensive osteolytic disease in the mandible of a pediatric patient
Case report
DOI:
https://doi.org/10.5935/2525-5711.20170012Palavras-chave:
Bone Diseases, Pathology, Bone Resorption, Osteolysis, EssentialResumo
Introduction: Gorham’s disease, correspond to a massive osteolytic disease of the bones, characterized by destruction and resorption of one or more bones, spontaneous and progressive. The etiology of the disease is still unknown. The destroyed bone does not have the ability to regenerate or repair and is replaced by dense fibrous tissue. Bones of the skull and pelvis are the most commonly affected and in maxillofacial bones, the mandible is particularly affected. Case report: This study reports the case of an 11-year- old female, referred to the Oral and Maxillofacial Surgery service showing extensive area of spontaneous bone resorption, in which only the alveolar portion of the mandibular symphysis and the head of the left jaw were present. The history and clinical features observed indicated Gorham’s disease. Final considerations: When in progressive stages Gorham’s disease is difficult to be diagnosed by histopathological evaluation, due to limited remaining bone quantity, leaving only clinical and complementary exams to make allowances. The treatment is controversial in the literature. Therapy is individualized in accordance with the severity of the patient’s condition and the site of involvement.
Referências
Gondivkar SM, Gadbail AR. Gorham-Stout syndrome: a rare clinical entity and review of literature. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010;109:e41-8.
Al-Jamali J, Glaum R, Kassem A, Voss PJ, Schmelzeisen R, Schön R. Gorham-Stout syndrome of the facial bones: a review of pathogenesis and treatment modalities and report of a case with a rare cutaneous manifestations. Oral Surg Oral Med Oral Pathol Oral Radiol. 2012;114:e23-9.
Frederikson NL, Wesley RK, Sciubba JJ, Helfrick J. Massive osteolysis of the maxillofacial skeleton: aclinical, radiologic, histologic and ultrstructural study. Oral Surg Oral Med Oral Pathol. 1983;55:470-80.
Gorham LW, Stout AP. Massive osteolysis (acute spontaneous absorption of bone, phantom bone, disappearing bone); its relation to hemangiomatosis. J Bone Joint Surg Am. 1955;37-A:985-1004.
Zhong LP, Zheng JW, Zhang WL, Zhang SY, Zhu HG, Ye WM, et al. Multicentric Gorham's disease in the oral and maxillofacial region: report of a case and review of the literature. J Oral Maxillofac Surg. 2008;66:1073-6.
Kiran DN, Anupama A. Vanising bone disease: a review. J Oral Maxillofac Surg. 2011;69:199-203.
Huang Y, Wangb L, Wena Y, Zhanga Q, Lia L. Progressively bilateral resorption of the mandible. J Craniomaxillofac Surg. 2012;40:174-7.
Ellati R, Attili A, Haddad H, Al-Hussaini M, Shehadeh A. Novel approach of treating Gorham-Stout disease in the humerus--Case report and review of literature. Eur Rev Med Pharmacol Sci. 2016;20:426-32.
Hammer F, Kenn W, Wesselmann U, Hofbauer LC, Delling G, Allolio B, et al. Gorham- Gorham-Stout disease--stabilization during bisphosphonate treatment. J Bone Min Res. 2005;20:350-3.
Patel DV. Gorham's disease of massive osteolysis. Clin Med Res. 2005;3:65-74.
Chan CK, Mohamed RM, Azlina AA, Azhar MM. Multicentric Disappearing Bone Disease treated with Arthroplasty. Malays Orthop J. 2016;10:42-5.
Tateda S, Aizawa T, Hashimoto K, Kanno H, Ohtsu S, Itoi E, et al. Successful Management of Gorham-Stout Disease in the Cervical Spine by Combined Conservative and Surgical Treatments: A Case Report. Tohoku J Exp Med. 2017;241:249-54.
Kim JW, Kang HJ, Kim DC, Shin CH. Gorham's disease in humerus treated with autogenous vascularized fibular graft. Indian J Orthop. 2017;51:217-21.
Rauh G, Gross M. Disappearing bone disease (Gorham-stout disease): report of a case with a follow-up of 48 years. Eur J Med Res. 1997;2:425-7.
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