Frequency and histoclinic pathology of malignant and potentially malignant disorders of oral cavity in Chile
DOI:
https://doi.org/10.5935/2525-5711.20170029Palavras-chave:
Mouth Neoplasms, Precancerous Conditions, ChileResumo
Introduction: Oral squamous cell carcinoma (OSCC) is the sixth most common type of cancer worldwide. Oral potentially malignant disorder (OPMD) represents a tissue where is more probably to occur a cancer in comparison with the apparently normal counterpart. Objective the purpose of this study was to determine the frequency and histoclinicpa- thology of these diseases in a Chilean population. This was a descriptive retrospective study. Material and Methods: Patients diagnosed with DPMO, OSCC and verrucous carcinoma (VC) treated in the Oral Medicine Clinic of University of Chile between 2005 and 2015 were selected, being revised the medical records and histopathological diagnoses. Results: From a sample of 241 patients, 60% were women and the mean age was 58 years. The prevalence of DPMO was 15%. The most prevalent of them was oral lichen planus (45%) follow by a 36% of leucoplakias, 16% of actinic cheilitis and 3% of erythroplakias. OSCC and VC accounted to 3.4% and 0.5% of the sample, respectively. The disease-free survival in 5 years for patients with OSCC was 39%. Conclusions: The results were similar to those reported by national and international studies must survival found was lower than reported.
Referências
India Project Team of the International Cancer Genome Consortium. Mutational landscape of gingivo-buccal oral squamous cell carcinoma reveals new recurrently-mutated genes and molecular subgroups. Nat Commun. 2013;4:2873.
Silverman S Jr. Demographics and occurrence of oral and pharyngeal cancers. The outcomes, the trends, the challenge. J Am Dent Assoc. 2001;132 Suppl:7S-11S.
Chung CH, Yang YH, Wang TY, Shieh TY, Warnakulasuriya S. Oral precancerous disorders associated with areca quid chewing, smoking, and alcohol drinking in southern Taiwan. J Oral Pathol Med. 2005;34:460-6.
Gillison ML. Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity. Semin Oncol. 2004;31:744-54.
Mashberg A. Diagnosis of early oral and oropharyngeal squamous carcinoma: obstacles and their amelioration. Oral Oncol. 2000;36:253-5.
Jimenez de la Jara J, Bastias G, Ferreccio C, Moscoso C, Sagues S, Cid C, et al. A snapshot of cancer in Chile: analytical frameworks for developing a cancer policy. Biol Res. 2015;48:10.
Rad M, Hashemipoor MA, Mojtahedi A, Zarei MZ, Chamani G, Kakoei S, et al. Correlation between clinical and histopathologic diagnoses of oral lichen planus based on modified WHO diagnostic criteria. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107:796-800.
Amarasinghe HK, Usgodaarachchi US, Johnson NW, Lalloo R, Warnakulasuriya S. Betel-quid chewing with or without tobacco is a major risk factor for oral potentially malignant disorders in Sri Lanka: a case-control study. Oral Oncol. 2010;46:297-301.
Warnakulasuriya S, Kovacevic T, Madden P, Coupland VH, Sperandio M, Odell E, et al. Factors predicting malignant transformation in oral potentially malignant disorders among patients accrued over a 10-year period in South East England. J Oral Pathol Med. 2011;40:677-83.
Axéll T, Pindborg JJ, Smith CJ, van der Waal I. Oral white lesions with special reference to precancerous and tobacco-related lesions: conclusions of an international symposium held in Uppsala, Sweden, May 18-21 1994. International Collaborative Group on Oral White Lesions. J Oral Pathol Med. 1996;25:49-54.
Kumar S, Debnath N, Ismail MB, Kumar A, Kumar A, Badiyani BK, et al. Prevalence and Risk Factors for Oral Potentially Malignant Disorders in Indian Population. Adv Prev Med. 2015;2015:208519.
Reichart PA, Philipsen HP. Oral erythroplakia-a review. Oral Oncol. 2005;41:551-61.
Rekha KP, Angadi PV. Verrucous carcinoma of the oral cavity: a clinico-pathologic appraisal of 133 cases in Indians. Oral Maxillofac Surg. 2010;14:211-8.
Dietrich T, Reichart PA, Scheifele C. Clinical risk factors of oral leukoplakia in a representative sample of the US population. Oral Oncol. 2004;40:158-63.
Reichart PA. Oral mucosal lesions in a representative crosssectional study of aging Germans. Community Dent Oral Epidemiol. 2000;28:390-8.
Ochsenius G, Ormeño A, Godoy L, Rojas R. A retrospective study of 232 cases of lip cancer and pre cancer in Chilean patients. Clinical-histological correlation. Rev Med Chil. 2003;131:60-6.
Candau Alvarez A, Dean Ferrer A, Alamillos Granados FJ, Heredero-Jung S, García-García B, Ruiz-Masera JJ, et al. Verrucous carcinoma of the oral mucosa: an epidemiological and follow-up study of patients treated with surgery in 5 last years. Med Oral Patol Oral Cir Bucal. 2014;19:e506-11.
Hassona Y, Scully C, Almangush A, Baqain Z, Sawair F. Oral potentially malignant disorders among dental patients: a pilot study in Jordan. Asian Pac J Cancer Prev. 2014;15:10427-31.
Borquez M P, Capdeville F F, Madrid M A, Veloso O M, Carcamo P M. Sobrevida global y por estadios de 137 pacientes con cáncer intraoral: Experiencia del Instituto Nacional del Cáncer. Rev Chil Cir. 2011;63:351-5.
Vitale-Cross L, Molinolo AA, Martin D, Younis RH, Maruyama T, Patel V, et al. Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions. Cancer Prev Res (Phila). 2012;5:562-73.
Mehdipour M, Taghavi Zenouz A, Farnam A, Attaran R, Farhang S, Safarnavadeh M, et al. The Relationship between Anger Expression and Its Indices and Oral Lichen Planus. Chonnam Med J. 2016;52:112-6.
Bouquot JE. Common oral lesions found during a mass screening examination. J Am Dent Assoc. 1986;112:50-7.
Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin. 2015;65:5-29.
Bánóczy J, Gintner Z, Dombi C. Tobacco use and oral leukoplakia. J Dent Educ. 2001;65:322-7.
Vallecillo Capilla M, Romero Olid MN, Olmedo Gaya MV, Reyes Botella C, Bustos Ruiz V. Factors related to survival from oral cancer in an Andalusian population sample (Spain). Med Oral Patol Oral Cir Bucal. 2007;12:E518-23.
Gaete J, Ortúzar C, Zitko P, Montgomery A, Araya R. Influence of school-related factors on smoking among Chilean adolescents: a cross-sectional multilevel study. BMC Pediatr. 2016;16:79.
Page RM, Danielson M. Multi-country, cross-national comparison of youth tobacco use: findings from global school-based health surveys. Addict Behav. 2011;36:470-8.
Tsai WC, Kung PT, Wang YH, Huang KH, Liu SA. Influence of time interval from diagnosis to treatment on survival for oral cavity cancer: A nationwide cohort study. 2017;12:e0175148.
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