Aggressive central giant cell granuloma in a child treated with a conservative surgical: a case report with 10-year follow-up

Dandara Menezes de Araujo Oliveira; Laura Luiza Trindade de Souza; Rodrigo Nascimento Lopes; Eduardo de Paula e Silva; Thais Bianca Brandão; Maria Stella Nunes Araujo Moreira; Clovis Antonio Lopes Pinto; André Caroli Rocha

doi:10.5327/2525-5711.422

Autores

Dandara Menezes de Araujo Oliveira A.C. Camargo Cancer Center, Department of Stomatology – São Paulo (SP), Brazil. https://orcid.org/0000-0002-7523-7980
Laura Luiza Trindade de Souza A.C. Camargo Cancer Center, Department of Stomatology – São Paulo (SP), Brazil. https://orcid.org/0000-0002-8956-9708
Rodrigo Nascimento Lopes A.C. Camargo Cancer Center, Department of Stomatology – São Paulo (SP), Brazil. https://orcid.org/0000-0002-5513-2794
Eduardo de Paula e Silva A.C. Camargo Cancer Center, Department of Stomatology – São Paulo (SP), Brazil.
Thais Bianca Brandão University of São Paulo Medical School, Institute of Cancer of São Paulo, Serviço de Odontologia Oncológica – São Paulo (SP), Brazil. https://orcid.org/0000-0001-9128-3138
Maria Stella Nunes Araujo Moreira A.C. Camargo Cancer Center, Department of Stomatology – São Paulo (SP), Brazil. https://orcid.org/0000-0002-4533-4544
Clovis Antonio Lopes Pinto A.C. Camargo Cancer Center, Department of Pathology – São Paulo (SP), Brazil. https://orcid.org/0000-0003-1711-0081
André Caroli Rocha A.C. Camargo Cancer Center, Department of Stomatology – São Paulo (SP), Brazil. https://orcid.org/0000-0003-0070-0640

DOI:

https://doi.org/10.5327/2525-5711.422

Palavras-chave:

Central giant cell granuloma, Surgery, Neoadjuvant therapy

Resumo

Central giant cell granuloma (CGCG) is a benign but sometimes aggressive intraosseous lesion that primarily affects the jaws. This report describes the clinical management and long-term follow-up of a 7-year-old male patient presenting with a refractory CGCG of the anterior mandible. Despite initial non-surgical treatment with intralesional corticosteroids, the lesion persisted and demonstrated expansion with cortical perforation and involvement of adjacent teeth. Conservative surgical excision was performed, requiring extraction of four teeth. Postoperative mandibular fracture occurred but healed with conservative management. The patient underwent orthodontic treatment and prosthetic rehabilitation, followed by alveolar ridge reconstruction with autogenous bone graft nine years later to allow dental implant placement. After 10 years of follow-up, no recurrence or new lesions were observed. This case highlights the challenges in managing aggressive CGCG in pediatric patients and supports conservative surgery combined with multidisciplinary rehabilitation as a viable approach.

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