Chronic periapical lesions: clinical and morphological characterization of 508 cases

Talytha Barbosa da Rocha; Raelly Katharinne Lima de Meneses; Nathália Yvia Assis Henriques; Jonh Lennon Silva Cunha; Manuel Antonio Gordón-Núñez; Cassiano Francisco Weege Nonaka; Pollianna Muniz  Alves

doi:10.5327/2525-5711.435

Autores

Talytha Barbosa da Rocha State University of Paraíba – Campina Grande (PB), Brazil. https://orcid.org/0000-0003-3855-9697
Raelly Katharinne Lima de Meneses State University of Paraíba – Campina Grande (PB), Brazil. https://orcid.org/0009-0000-0552-1241
Nathália Yvia Assis Henriques State University of Paraíba – Campina Grande (PB), Brazil. https://orcid.org/0009-0001-1319-1104
Jonh Lennon Silva Cunha State University of Paraíba – Campina Grande (PB), Brazil. https://orcid.org/0000-0002-0679-8485
Manuel Antonio Gordón-Núñez State University of Paraíba – Campina Grande (PB), Brazil. https://orcid.org/0000-0001-6952-4265
Cassiano Francisco Weege Nonaka State University of Paraíba – Campina Grande (PB), Brazil. https://orcid.org/0000-0003-2380-109X
Pollianna Muniz Alves State University of Paraíba – Campina Grande (PB), Brazil. https://orcid.org/0000-0003-1297-4032

DOI:

https://doi.org/10.5327/2525-5711.435

Palavras-chave:

Odontogenic Cyst, Radicular Cyst, Periapical Granuloma, Residual Radicular Cyst

Resumo

Objective: To evaluate the clinical and morphological findings of chronic periapical lesions (CPL) composed of periapical granuloma (PG), radicular cyst (RC), and residual radicular cyst (RRC). Methods: Sample was collected from an Oral Pathology Service over 10-year period. Histomorphological analysis was performed qualitatively. For estatistical analysis were used Fischer’s exact and Q2 tests, considering value p<0.05. Results: Among the 4.808 cases retrieved from the service, 508 (10.6%) cases were CPL. PG was the most frequent lesion (n=264; 51.96%). RC and PG were more prevalent among young adults, while RRC affected older patients (p<0.0001). Morphologically, lower grade of intensity of the inflammatory infiltrate (Grade I) was founded in RRC, compared to PG and RC (Grade II/III) (p<0.0001). Atrophic epithelium was more present in RRC, whereas hyperplastic epithelium was more observed in RC (p=0.012). Russell bodies and foamy macrophages were more frequent in PG (p<0.05). Rushton bodies and negative images of cholesterol crystals were more observed in RC (p<0.05). Conclusions: CPL are a common condition frequently associated with persistent endodontic infection and represent a significant clinical challenge in dental practice. Therefore, clinical and morphological comprehensive characterization of CPL is important for their correct diagnosis and treatment.

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