A rare case of oral metastasis of renal clear cell carcinoma
case report and review of literature
DOI:
https://doi.org/10.5935/2525-5711.20200006Palavras-chave:
Oral Manifestatios, Carcinoma, Renal Cell, GingivaResumo
This is a case report of metastasis of renal clear cell carcinoma, a very rare malignant neoplasia, in the oral cavity. The patient went to the oral medicine clinic complaining of a nodule in the left upper gingival region that had started a month previously. Clinical evaluation revealed a large, red and bleeding nodule in the superior gingiva of the left side of the maxilla. A panoramic radiographic revealed alveolar bone destruction. Incisional biopsy was performed, and microscopic evaluation revealed an unspecified malignant neo- plasia. The patient was referred to a local hospital for investigation. A systemic evaluation showed a large nodule in the right kidney, another nodule in the liver, small nodules in both lungs and two nodules in the brain. A biopsy of the right kidney was performed, showing a renal clear cell carcinoma. After that, new immunohistochemical analysis of the oral lesion was performed demonstrating it to be one more implant of renal neopla- sia. The final diagnosis was renal clear cell carcinoma, with metastases in the liver, lung, mouth and nervous system. Unfortunately, the patient died six months after the diagnosis. The primary tumour was only discovered due to the oral manifestation of the disease, emphasising the importance of oral medicine in the diagnosis of metastatic lesions.
Referências
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424.
Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumours to the oral cavity - pathogenesis and analysis of 673 cases. Oral Oncol. 2008 Aug;44(8):743-52.
Liu Y, Vargo RJ, Bilodeau EA. Analytic survey of 57 cases of oral metastases. J Oral Pathol Med. 2018;47(3):275-80.
Suojanen J, Färkkilä E, Helkamaa T, Loimu V, Törnwall J, Lindqvist C, et al. Rapidly growing and ulcerating metastatic renal cell carcinoma of the lower lip: a case report and review of the literature. Oncol Lett. 2014 Nov;8(5):2175-8.
Morita Y, Iwagami T, Kawakita C, Kusuyama Y, Niki-Yonekawa A, Morita N. Oral metastasis of renal cell carcinoma mimicking recurrence of excised malignant myoepithelioma: a case report. Mol Clin Oncol. 2018 Jul;9(1):66-9.
Ali RAE, Mohamed KEH. Metastatic clear cell renal cell carcinoma presenting with a gingival metastasis. Clin Pract. 2016 Jun;6(2):847.
Schwab B, Lee WT. Bilateral renal cell carcinoma metastasis in the oral cavity. Am J Otolaryngol. 2012;33(1):154-5.
Matamala GN, Ángeles MDL, Toro F. Oral metastasis of renal cell carcinoma, presentation of a case. Med Oral Patol Oral Cir Bucal. 2008 Nov;13(11):E742-4.
Altuntaş O, Petekkaya İ, Süslü N, Güllü İ. Renal cell carcinoma metastatic to the tongue: a case report and review of the literature. J Oral Maxillofac Surg. 2015 Jan;73(6):1227-30.
Vasilyeva D, Peters SM, Philipone EM, Yoon AJ. Renal cell carcinoma metastatic to the maxillary gingiva: a case report and review of the literature. J Oral Maxillofac Pathol [Internet]. 2018 Feb; 22(4):102-7. Available from: http://www.jomfp.in/text.asp?2018/22/4/102/224631
Zhang L, Yang H, Zhang X. Metastatic renal cell carcinoma to the jaws: report of cases. World J Surg Oncol. 2014;12(1):204.
Umer M, Mohib Y, Atif M, Nazim M. Skeletal metastasis in renal cell carcinoma: a review. Ann Med Surg. 2018 Jan;27:9-16.
Guevremont C, Jeldres C, Perrotte P, Karakiewicz PI. Sorafenib in the management of metastatic renal cell carcinoma. Curr Oncol. 2009;16(Suppl 1):S27-32.
Kaplan I, Raiser V, Shuster A, Shlomi B, Rosenfeld E, Greenberg A, et al. Metastatic tumors in oral mucosa and jawbones: unusual primary origins and unusual oral locations. Acta Histochem. 2019 Nov;121(8):151448.
Yoshitomi I, Kawasaki G, Mizuno A, Nishikido M, Hayashi T, Fujita S, et al. Lingual metastasis as an initial presentation of renal cell carcinoma. Med Oncol. 2011;28(4):1389-94.
Derakhshan S, Rahrotaban S, Mahdavi N, Mirjalili F. Metastatic renal cell carcinoma presenting as maxillary lesion: report of two rare cases. J Oral Maxillofac Pathol. 2018 Jan;22(Suppl 1):S39-43.
Ganini C, Lasagna A, Ferraris E, Gatti P, Paglino C, Imarisio I, et al. Lingual metastasis from renal cell carcinoma: a case report and literature review. Rare Tumors. 2012 Aug;4(3):130-3.
Jallu A, Latoo M, Pampori R. Rare case of renal cell carcinoma with mandibular swelling as primary presentation. Case Rep Urol. 2013 Jun;2013:806192.
Morvan JB, Veyrières JB, Mimouni O, Cathelinaud O, Allali L, Verdalle P. Clear-cell renal carcinoma metastasis to the base of the tongue and sphenoid sinus: two very rare atypical ENT locations. Eur Ann Otorhinolaryngol Head Neck Dis. 2011 Apr;128(2):91-4.
Majewska H, Skálová A, Radecka K, Stodulski D, Hyrcza M, Stankiewicz C, et al. Renal clear cell carcinoma metastasis to salivary glands - a series of 9 cases: clinico-pathological study. Pol J Pathol. 2016 Mar;67(1):39-45.
Jatti D, Puri G, Aravinda K, Dheer DS. An atypical metastasis of renal clear cell carcinoma to the upper lip: a case report. J Oral Maxillofac Surg. 2015 Feb;73(2):371.e1-e6. DOI: http://dx.doi.org/10.1016/j.joms.2014.09.006
Lee C, Park JW, Suh J, Nam KH, Moon KC. Histologic variations and immunohistochemical features of metastatic clear cell renal cell carcinoma. Korean J Pathol. 2013 Oct;47(5):426-32.
Ma F, Dai L, Wang Z, Zhou L, Niu Y, Jiang N. Correction: evaluating prognosis by CK7 differentiating renal cell carcinomas from oncocytomas can be used as a promising tool for optimizing diagnosis strategies. Oncotarget. 2018 Jun;9(49):29285.
Netto R, Freitas Filho SAJ, Cortezzi W, Merly F, Andrade VM, Pires FR. Metastasis of renal cell carcinoma causing significant facial asymmetry. Case Rep Surg. 2019 Nov;2019:6840873.
Costantino C, Thomas GV, Ryan C, Coakley FV, Troxell ML, Li X, et al. Metastatic renal cell carcinoma without evidence of a renal primary. Int Urol Nephrol. 2015 Nov;48(1):73-7.
Rini BI, Plimack ER, Takagi T, Elson P, Wood LS, Dreicer R, et al. A phase II study of pazopanib in patients with localized renal cell carcinoma to optimize preservation of renal parenchyma. J Urol. 2015 Mar;194(2):297-303. DOI: http://dx.doi.org/10.1016/j.juro.2015.03.096
Leksell L. Occasional review stereotactic radiosurgery. J Neurol Neurosurg Psychiatry. 1983 Sep;46(9):797-803.
Costantino C, Thomas GV, Ryan C, Coakley FV, Troxell ML. Metastatic renal cell carcinoma without evidence of a renal primary.
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Copyright (c) 1969 Luan Nathiel Santana Kovalski, Julia Turra Ribeiro, Manoela Domingues Martins, Marcia Gaiger De Oliveira, Luis Fernando Rivero, Vinicius Coelho Carrard, Marco Antonio Trevizani Martins
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.