A Rare Bone Tumor of the Mandible: Chondromyxoid Fibroma

Wilson Alejandro Delgado Azañero; Jaime Orlando Huamaní Parra; Hugo Dante Ghersi Miranda; Hugo Aguayo Olivares; Mauricio Grover Cordero Peña; Nathalie Leonela Gonzales Pizarro; Katman Bear Toledo Sanchez

doi:10.5327/2525-5711.444

Authors

Wilson Alejandro Delgado Azañero Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0000-0001-8116-2375
Jaime Orlando Huamaní Parra Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0000-0002-6191-9331
Hugo Dante Ghersi Miranda Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0000-0002-8866-3196
Hugo Aguayo Olivares Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0009-0000-9520-6041
Mauricio Grover Cordero Peña Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0009-0002-6634-6963
Nathalie Leonela Gonzales Pizarro Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0009-0005-1352-9979
Katman Bear Toledo Sanchez Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0000-0002-9082-1800

DOI:

https://doi.org/10.5327/2525-5711.444

Keywords:

Chondromyxoid fibroma, mandible, immunohistochemistry, chondrogenic neoplasms, jaw neoplasms

Abstract

Chondromyxoid fibroma is a rare benign bone tumor composed of chondroid and myxoid tissue, multinucleated giant cells, and mineralized areas. It primarily affects the long bones of young adults, and its occurrence in the maxillofacial region is extremely uncommon, with only 34 cases reported in the English-language literature. Radiographically, it may be confused with fibro-osseous lesions such as ossifying fibroma. We present a mandibular case in a 29-year-old woman, including histological analysis with H&E and immunohistochemical staining for α-SMA, vimentin, S-100, CD10, Ki-67, and p53. A six-year clinical and radiographic follow-up is also included.

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