A Rare Bone Tumor of the Mandible: Chondromyxoid Fibroma

Wilson Alejandro Delgado Azañero; Jaime Orlando Huamaní Parra; Hugo Dante Ghersi Miranda; Hugo Aguayo Olivares; Mauricio Grover Cordero Peña; Nathalie Leonela Gonzales Pizarro; Katman Bear Toledo Sanchez

doi:10.5327/2525-5711.444

Autores/as

Wilson Alejandro Delgado Azañero Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0000-0001-8116-2375
Jaime Orlando Huamaní Parra Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0000-0002-6191-9331
Hugo Dante Ghersi Miranda Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0000-0002-8866-3196
Hugo Aguayo Olivares Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0009-0000-9520-6041
Mauricio Grover Cordero Peña Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0009-0002-6634-6963
Nathalie Leonela Gonzales Pizarro Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0009-0005-1352-9979
Katman Bear Toledo Sanchez Universidad Peruana Cayetano Heredia, Faculty of Stomatology, Buccomaxillofacial, Department of Medicine and Surgery – Lima, Perú. https://orcid.org/0000-0002-9082-1800

DOI:

https://doi.org/10.5327/2525-5711.444

Palabras clave:

Chondromyxoid fibroma, mandible, immunohistochemistry, chondrogenic neoplasms, jaw neoplasms

Resumen

Chondromyxoid fibroma is a rare benign bone tumor composed of chondroid and myxoid tissue, multinucleated giant cells, and mineralized areas. It primarily affects the long bones of young adults, and its occurrence in the maxillofacial region is extremely uncommon, with only 34 cases reported in the English-language literature. Radiographically, it may be confused with fibro-osseous lesions such as ossifying fibroma. We present a mandibular case in a 29-year-old woman, including histological analysis with H&E and immunohistochemical staining for α-SMA, vimentin, S-100, CD10, Ki-67, and p53. A six-year clinical and radiographic follow-up is also included.

Citas

1. Rahimi A, Beabout JW, Ivins JC, Dahlin DC. Myxoma of bone: report of 34 cases. Cancer. 1972;30(2):539–48.

2. Grotepass FW, Farman AG, Nortjé CJ. Myxofibroma of the jaw. J Oral Maxillofac Surg. 1986;44(6):484–9.

3. Castle JT, Kernig ML. Fibromyxoma (myxofibroma) of the mandibular angle: case report. Head Neck Pathol. 2011;5(4):406–9. doi: 10.1007/s12105-011-0282-2.

4. Baranović M, Manojlović S, Milić M, Lukšić I, Virag M, Dediol E. Myxofibroma of the mandible: a case report. Coll Antropol. 2012;36(1):287–90.

5. Strek P, Zagólski O, Składzień J, Oleś K, Kurzyński M. Fibromyxoma of the mandibular ramus: a case report and review of the literature. Auris Nasus Larynx. 2013;40(3):312–5. doi: 10.1016/j.anl.2012.07.009.

6. Fomete B, Adebayo ET, Ayuba GI, Ogbeifun JO. Fibromyxoma of the mandible: a case report and review of the literature. Pan Afr Med J. 2014; 17:54. doi: 10.11604/pamj.2014.17.54.3404.

7. Pintor MF, Marengo G, Brito A, Villanueva J, Martinez B, Cornejo M. Fibromyxoma of the zygomaticomaxillary region: case report. J Oral Maxillofac Surg. 2015;73(5):891–6. doi: 10.1016/j.joms.2014.11.012.

8. Cardemil C, Thomsen P, Persson M, Götrick B. Fibromyxoma of the maxilla: a case report and review of the literature. J Oral Maxillofac Surg. 2016;74(10):2075–82. doi: 10.1016/j.joms.2016.05.017.

9. Khatib B, Pogrel MA. Fibromyxoma of the mandibular body: report of a case with cone beam computed tomographic findings. J Oral Maxillofac Surg. 2018;76(7):1513–8. doi: 10.1016/j.joms.2018.01.026.

10. Florescu A, Simionescu C, Georgescu CV, Ciucă EM, Rascanu CI, Bătăiosu M. Fibromyxoma of the posterior mandible: a case report. Rom J Morphol Embryol. 2019;60(2):623–7.

11. Hassan W, Ghali S. Fibromyxoma of the anterior maxilla: a case report and literature review. J Oral Maxillofac Res. 2020;11(2):e5. doi: 10.5037/jomr.2020.11205.

12. Terzic A, Debelmas A, Laplace-Builhé B, Espitalier F, Corre P, Bertin H. Recurrent fibromyxoma of the mandible managed with the Eve procedure: a case report. J Craniomaxillofac Surg. 2020;48(6):603–7. doi: 10.1016/j.jcms.2020.04.008.

13. Elseyoufi MA, Mohamedean A, Younis RH. Fibromyxoma of the mandible with S-100 positive chondroid areas: a case report with immunohistochemical analysis. Head Neck Pathol. 2021;15(3):1006–12. doi: 10.1007/s12105-020-01266-3.

14. Panucci GL, Coppola M, Caristo R, Di Nola C, Caristo G, Tregnaghi A. Fibromyxoma of the anterior maxilla in a 1-year-old patient: case report with immunohistochemical findings. J Oral Maxillofac Surg. 2021;79(3):585–91. doi: 10.1016/j.joms.2020.10.018.

15. Elzouiti B, Lahmiti S, Chaibdraa A, Hafid MA. Fibromyxoma of the zygomatic arch in an elderly patient: a rare case report. J Stomatol Oral Maxillofac Surg. 2022;123(6):e794–7. doi: 10.1016/j.jormas.2022.06.022.

16. Jadaun S, Singh S, Bhargava R, Yadav R. Giant fibromyxoma of the mandible extending to the condyle in an adolescent: a case report with long-term follow-up. J Oral Maxillofac Surg. 2023;81(5):598–605. doi: 10.1016/j.joms.2022.12.014.

17. Moreno-García C, González-García R, Marín-Fernández AB, Monje-Gil F. Fibromyxoma of the ascending mandibular ramus: case report and review of the literature. J Clin Exp Dent. 2023;15(4):e367–72. doi: 10.4317/jced.60411.

18. Li X, Gong Y. Fibromyxoma of the temporomandibular joint with intracranial involvement: a case report with MRI and immunohistochemical findings. Oral Surg Oral Med Oral Pathol Oral Radiol. 2024;137(4):e125–31. doi: 10.1016/j.oooo.2023.11.008.

19. Watabe T, Yusa K, Tachibana H, Yoshida H, Sano K. Fibromyxoma of the anterior maxilla in a 1-year-old child: a case report. Int J Oral Maxillofac Surg. 2024;53(2):138–42. doi: 10.1016/j.ijom.2023.07.005.

20. Shahriar Rubel MS, Hossain MD, Rahman MM, Islam MS. Recurrent fibromyxoma of the upper maxilla treated with class III maxillectomy: a case report. J Oral Maxillofac Surg Med Pathol. 2025;37(1):45–50. doi: 10.1016/j.ajoms.2024.09.004.

21. Lodhia P, Mukherjee S, Ghosh S, Mehrotra D. Fibromyxoma of the mandibular angle and ramus: report of a case and systematic review. J Maxillofac Oral Surg. 2025;24(2):301–8. doi: 10.1007/s12663-024-02351-0.

22. World Health Organization Classification of Tumours Editorial Board. WHO Classification of Tumours: Soft Tissue and Bone Tumours. 5th ed. Lyon: IARC Press; 2020.

23. WHO Classification of Head and Neck Tumours. 5th ed. Lyon: IARC Press; 2022.

24. Neville BW, Damm DD, Allen CM, Chi AC. Oral and Maxillofacial Pathology. 4th ed. Philadelphia: Elsevier; 2016. p. 612–4.

25. Li TJ, Sun LS, Luo HY. Odontogenic myxoma: a clinicopathologic study of 25 cases. Arch Pathol Lab Med. 2006;130(12):1799–806. doi: 10.5858/2006-130-1799-OMACSO.

26. Simon EN, Merkx MA, Vuhahula E, Ngassapa D, Stoelinga PJ. Odontogenic myxoma: a clinicopathological study of 33 cases. Int J Oral Maxillofac Surg. 2004;33(4):333–7. doi: 10.1016/j.ijom.2003.10.015.

27. Kaffe I, Naor H, Buchner A. Clinical and radiological features of odontogenic myxoma of the jaws. Dentomaxillofac Radiol. 1997;26(5):299–303. doi: 10.1038/sj.dmfr.4600266.

28. Slootweg PJ. Lesions of the jaws. Histopathology. 2009;54(4):401–18. doi: 10.1111/j.1365-2559.2008.03097.x.