Late diagnosis and oral rehabilitation in a patient with Cowden syndrome: case report

Gabriel Miranda de Oliveira Abdalla; Letícia Maria Cotta; Caroline Miranda Pernambuco; Alexandra Goulart Silvério; Carine Ervolino de Oliveira; Marcela Filié Haddad; Leonardo Amaral dos Reis

doi:10.5327/2525-5711.416

Autores/as

Gabriel Miranda de Oliveira Abdalla Federal University of Alfenas, School of Dentistry – Alfenas (MG), Brazil. https://orcid.org/0009-0002-7990-3888
Letícia Maria Cotta Federal University of Alfenas, School of Dentistry – Alfenas (MG), Brazil. https://orcid.org/0009-0009-6344-3507
Caroline Miranda Pernambuco Federal University of Alfenas, School of Dentistry – Alfenas (MG), Brazil. https://orcid.org/0009-0005-7090-5432
Alexandra Goulart Silvério Federal University of Alfenas, School of Dentistry – Alfenas (MG), Brazil. https://orcid.org/0009-0001-0762-0726
Carine Ervolino de Oliveira Federal University of Alfenas, School of Dentistry – Alfenas (MG), Brazil. https://orcid.org/0000-0003-3103-090X
Marcela Filié Haddad Federal University of Alfenas, School of Dentistry – Alfenas (MG), Brazil. https://orcid.org/0000-0003-3455-6624
Leonardo Amaral dos Reis Federal University of Alfenas, School of Dentistry – Alfenas (MG), Brazil. https://orcid.org/0000-0003-0701-1565

DOI:

https://doi.org/10.5327/2525-5711.416

Palabras clave:

Cowden Syndrome, PTEN Tumor Suppressor Gene, Oral Manifestations, Case Report, Oral Rehabilitation

Resumen

Cowden syndrome is a rare autosomal dominant disorder associated with germline mutations in the PTEN gene and characterized by multiple hamartomas and an increased risk of malignancy. A 64-year-old woman was referred for evaluation of papillomatous lesions in the oral cavity. Clinical examination revealed verrucous lesions, macrocephaly, acral keratoses, and facial trichilemmomas. Complementary examinations showed benign breast nodules and gastrointestinal polyposis without malignant transformation. Based on clinical, histopathological, and imaging findings, a diagnosis of Cowden syndrome was established according to the criteria of the International Cowden Syndrome Consortium. The patient underwent surgical excision of the oral papillomatous lesions followed by prosthetic rehabilitation with complete removable dentures, which restored function and aesthetics. This report emphasizes the essential role of dentists in the recognition of Cowden syndrome and in the multidisciplinary management required for affected patients.

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